OBJECTIVE: To investigate the association between the genetic polymorphisms of myxovirus resistance 1 (MxA) gene and susceptibility to severe acute respiratory syndromes (SARS). METHODS: A case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the T/G polymorphism at position-88 in the mxA gene promoter. Information on related factors of SARS was collected using a pre-testing questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package. RESULTS: Sixty-six cases and sixty-four controls were selected for the study. Comparing with GG genotype, the proportion of GT genotype were significantly higher in the case group (81.3%) than that in the control group (62.5%)) with an OR (95% CI) of 2.700 (1.208-6.037). Multivariate logistic regression analysis revealed that the significant association remained after factors as wearing masks, protection gowns and eye-protection when contacting with SARS patient etc. were adjusted with an OR (95 % CI) of 2.911 (1.027-8.250). CONCLUSION: mxA promoter-88G/T SNP might be confered to host genetic susceptibility to SARS in Chinese Han population.
OBJECTIVE: To investigate the association between the genetic polymorphisms of myxovirus resistance 1 (MxA) gene and susceptibility to severe acute respiratory syndromes (SARS). METHODS: A case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the T/G polymorphism at position-88 in the mxA gene promoter. Information on related factors of SARS was collected using a pre-testing questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package. RESULTS: Sixty-six cases and sixty-four controls were selected for the study. Comparing with GG genotype, the proportion of GT genotype were significantly higher in the case group (81.3%) than that in the control group (62.5%)) with an OR (95% CI) of 2.700 (1.208-6.037). Multivariate logistic regression analysis revealed that the significant association remained after factors as wearing masks, protection gowns and eye-protection when contacting with SARSpatient etc. were adjusted with an OR (95 % CI) of 2.911 (1.027-8.250). CONCLUSION:mxA promoter-88G/T SNP might be confered to host genetic susceptibility to SARS in Chinese Han population.
Authors: Tom Jefferson; Chris B Del Mar; Liz Dooley; Eliana Ferroni; Lubna A Al-Ansary; Ghada A Bawazeer; Mieke L van Driel; Sreekumaran Nair; Mark A Jones; Sarah Thorning; John M Conly Journal: Cochrane Database Syst Rev Date: 2011-07-06
Authors: Omar Ramos-Lopez; Lidia Daimiel; Ana Ramírez de Molina; Diego Martínez-Urbistondo; Juan A Vargas; J Alfredo Martínez Journal: Int J Genomics Date: 2020-10-19 Impact factor: 2.326
Authors: Tom Jefferson; Ruth Foxlee; Chris Del Mar; Liz Dooley; Eliana Ferroni; Bill Hewak; Adi Prabhala; Sreekumaran Nair; Alessandro Rivetti Journal: Evid Based Child Health Date: 2008-12-10
Authors: Tom Jefferson; Chris B Del Mar; Liz Dooley; Eliana Ferroni; Lubna A Al-Ansary; Ghada A Bawazeer; Mieke L van Driel; Mark A Jones; Sarah Thorning; Elaine M Beller; Justin Clark; Tammy C Hoffmann; Paul P Glasziou; John M Conly Journal: Cochrane Database Syst Rev Date: 2020-11-20