Literature DB >> 16387678

The vaccinia virus N1L protein influences cytokine secretion in vitro after infection.

Zhouning Zhang1, Melissa-Rose Abrahams, Lawrence A Hunt, Jill Suttles, William Marshall, Debomoy K Lahiri, Girish J Kotwal.   

Abstract

The vaccinia virus N1L ORF encodes a protein that enhances virulence and replication of the virus by an unknown mechanism. It has been studied for its ability to enhance viral replication and dissemination in the brain and more recently has been linked to an immunomodulatory role in which it inhibits the activation of cytokine transcription activators in Toll-like receptor signaling pathways after pathogen recognition. The effect of N1L on the release of cytokines from human primary monocytes was investigated. Secretion of the proinflammatory, antiviral cytokines TNF-alpha, IL-1beta, IFN-alpha, IFN-beta, and the anti-inflammatory cytokine IL-10 was found to be inhibited by the presence of the N1L protein.

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Year:  2005        PMID： 16387678     DOI： 10.1196/annals.1352.005

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  11 in total

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4.  Gamma interferon-induced interferon regulatory factor 1-dependent antiviral response inhibits vaccinia virus replication in mouse but not human fibroblasts.

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7.  Combined Proteomics/Genomics Approach Reveals Proteomic Changes of Mature Virions as a Novel Poxvirus Adaptation Mechanism.

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8.  Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection.

Authors:  Nathalie Jacobs; Nathan W Bartlett; Richard H Clark; Geoffrey L Smith
Journal:  J Gen Virol       Date:  2008-11       Impact factor: 3.891

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Journal:  PLoS One       Date:  2012-10-31       Impact factor: 3.240

10.  Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus.

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Journal:  PLoS One       Date:  2008-10-02       Impact factor: 3.240
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