| Literature DB >> 16387495 |
Stéphane L Bogen1, Sumei Ruan, Rong Liu, Sony Agrawal, John Pichardo, Andrew Prongay, Bahige Baroudy, Anil K Saksena, Viyyoor Girijavallabhan, F George Njoroge.
Abstract
Depeptidization efforts of the P(3)-P(2) region of P(3) capped alpha-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P(2) nitrogen and modification of the P(2)' carboxylic acid terminus were essential for activity in the replicon assay.Entities:
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Year: 2006 PMID： 16387495 DOI： 10.1016/j.bmcl.2005.12.013
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823