| Literature DB >> 16387425 |
P Borst1, N Zelcer, K van de Wetering.
Abstract
MRPs are membrane proteins transporting organic anions at the expense of ATP hydrolysis. MRP2 is known to be a major transporter of organic anions from the liver into bile. We discuss recent results showing allosteric control of human but not rat MRP2. MRP3 has been considered a major player in bile salt metabolism, but our recent results with Mrp3 KO mice do not support this. Instead, we have found a role for MRP3 in the cellular export of drug-glucuronide conjugates. We discuss problems in extrapolating results obtained for murine MRPs.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16387425 DOI： 10.1016/j.canlet.2005.05.051
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679