Literature DB >> 16386905

1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.

Sean R Klopfenstein1, Artem G Evdokimov, Anny-Odile Colson, Neil T Fairweather, Jeffrey J Neuman, Matthew B Maier, Jeffrey L Gray, Gina S Gerwe, George E Stake, Brian W Howard, Julie A Farmer, Matthew E Pokross, Thomas R Downs, Bhavani Kasibhatla, Kevin G Peters.   

Abstract

High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16386905     DOI： 10.1016/j.bmcl.2005.12.051

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  High-resolution dose-response screening using droplet-based microfluidics.

Authors:  Oliver J Miller; Abdeslam El Harrak; Thomas Mangeat; Jean-Christophe Baret; Lucas Frenz; Bachir El Debs; Estelle Mayot; Michael L Samuels; Eamonn K Rooney; Pierre Dieu; Martin Galvan; Darren R Link; Andrew D Griffiths
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-27       Impact factor: 11.205

Review 2.  Microfluidics: reframing biological enquiry.

Authors:  Todd A Duncombe; Augusto M Tentori; Amy E Herr
Journal:  Nat Rev Mol Cell Biol       Date:  2015-09       Impact factor: 94.444

3.  Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.

Authors:  Jikui Shen; Maike Frye; Bonnie L Lee; Jessica L Reinardy; Joseph M McClung; Kun Ding; Masashi Kojima; Huiming Xia; Christopher Seidel; Raquel Lima e Silva; Aling Dong; Sean F Hackett; Jiangxia Wang; Brian W Howard; Dietmar Vestweber; Christopher D Kontos; Kevin G Peters; Peter A Campochiaro
Journal:  J Clin Invest       Date:  2014-09-02       Impact factor: 14.808

Review 4.  Targeting Tyrosine Phosphatases: Time to End the Stigma.

Authors:  Stephanie M Stanford; Nunzio Bottini
Journal:  Trends Pharmacol Sci       Date:  2017-04-12       Impact factor: 14.819

5.  Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.

Authors:  Dusica Vidović; Stephan C Schürer
Journal:  J Med Chem       Date:  2009-11-12       Impact factor: 7.446

6.  Identification of Cryptic Binding Sites Using MixMD with Standard and Accelerated Molecular Dynamics.

Authors:  Richard D Smith; Heather A Carlson
Journal:  J Chem Inf Model       Date:  2021-02-18       Impact factor: 4.956

7.  AutoClickChem: click chemistry in silico.

Authors:  Jacob D Durrant; J Andrew McCammon
Journal:  PLoS Comput Biol       Date:  2012-03-15       Impact factor: 4.475

8.  Novel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies.

Authors:  Marie Jazmín Sarabia-Sánchez; Pedro Josué Trejo-Soto; José Miguel Velázquez-López; Carlos Carvente-García; Rafael Castillo; Alicia Hernández-Campos; Claudia Avitia-Domínguez; Daniel Enríquez-Mendiola; Erick Sierra-Campos; Mónica Valdez-Solana; José Manuel Salas-Pacheco; Alfredo Téllez-Valencia
Journal:  Molecules       Date:  2017-12-20       Impact factor: 4.411

9.  Molecular Dynamics Simulations of A27S and K120A Mutated PTP1B Reveals Selective Binding of the Bidentate Inhibitor.

Authors:  Xi Chen; Xia Liu; Qiang Gan; Changgen Feng; Qian Zhang
Journal:  Biomed Res Int       Date:  2019-01-08       Impact factor: 3.411

10.  Molecular docking and virtual screening for novel protein tyrosine phosphatase 1B (PTP1B) inhibitors.

Authors:  Pasupuleti Sreenivasa Rao; Charuvaka Muvva; Karli Geethanjali; Suresh Babu Bastipati; Rajitha Kalashikam
Journal:  Bioinformation       Date:  2012-09-11
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.