| Literature DB >> 16386902 |
Brian E Fink1, Ashvinikumar V Gavai, John S Tokarski, Bindu Goyal, Raj Misra, Hai-Yun Xiao, S David Kimball, Wen-Ching Han, Derek Norris, Thomas E Spires, Dan You, Marco M Gottardis, Matthew V Lorenzi, Gregory D Vite.
Abstract
A novel series of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17beta-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays.Entities:
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Year: 2006 PMID： 16386902 DOI： 10.1016/j.bmcl.2005.12.039
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823