BACKGROUND: Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pleuripotent hematopoietic progenitor cells characterized by excessive proliferation and accumulation of granulocytes and occasionally red blood cells and platelets. METHODS: We examined 30 newly diagnosed and proved cases of CML admitted in medical wards or attending a clinical hematology clinic. In addition to routine hematological investigations, lipid profile was done in all the patients at the time of presentation, 4-6 weeks after the start of chemotherapy and 6 months after the chemotherapy even if some of the patients were not in remission. RESULTS: Total serum cholesterol, HDL-cholesterol and LDL-cholesterol concentrations increased significantly after chemotherapy whereas serum triglyceride and VLDL-C cholesterol concentrations did not increase significantly. Also, lipid concentrations were correlated with disease activity. An inverse correlation was found with spleen size and total serum cholesterol, HDL-cholesterol and LDL-cholesterol. Serum triglyceride and VLDL-C concentrations were inversely related to the hemoglobin concentrations. There was no correlation of total cholesterol and LDL-cholesterol concentrations with hemoglobin. We found from the present study that low lipid concentrations are associated with poor prognosis of the disease. CONCLUSION: We suggest that the estimation of lipid profile may be helpful in evaluating the response to chemotherapy in CML patients.
BACKGROUND:Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pleuripotent hematopoietic progenitor cells characterized by excessive proliferation and accumulation of granulocytes and occasionally red blood cells and platelets. METHODS: We examined 30 newly diagnosed and proved cases of CML admitted in medical wards or attending a clinical hematology clinic. In addition to routine hematological investigations, lipid profile was done in all the patients at the time of presentation, 4-6 weeks after the start of chemotherapy and 6 months after the chemotherapy even if some of the patients were not in remission. RESULTS: Total serum cholesterol, HDL-cholesterol and LDL-cholesterol concentrations increased significantly after chemotherapy whereas serum triglyceride and VLDL-Ccholesterol concentrations did not increase significantly. Also, lipid concentrations were correlated with disease activity. An inverse correlation was found with spleen size and total serum cholesterol, HDL-cholesterol and LDL-cholesterol. Serum triglyceride and VLDL-C concentrations were inversely related to the hemoglobin concentrations. There was no correlation of total cholesterol and LDL-cholesterol concentrations with hemoglobin. We found from the present study that low lipid concentrations are associated with poor prognosis of the disease. CONCLUSION: We suggest that the estimation of lipid profile may be helpful in evaluating the response to chemotherapy in CMLpatients.
Authors: Nicole Paulin; Yvonne Döring; Sander Kooijman; Xavier Blanchet; Joana R Viola; Renske de Jong; Manuela Mandl; Jeffrey Hendrikse; Maximilian Schiener; Philipp von Hundelshausen; Anja Vogt; Christian Weber; Khalil Bdeir; Susanna M Hofmann; Patrick C N Rensen; Maik Drechsler; Oliver Soehnlein Journal: EBioMedicine Date: 2017-01-07 Impact factor: 8.143
Authors: Mohammed Hussein Kamareddine; Youssef Ghosn; Antonios Tawk; Carlos Elia; Walid Alam; Joseph Makdessi; Said Farhat Journal: Technol Cancer Res Treat Date: 2019 Jan-Dec