Literature DB >> 16385008

Solution structure of the C4 zinc finger domain of HDM2.

Grace W Yu1, Mark D Allen, Antonina Andreeva, Alan R Fersht, Mark Bycroft.   

Abstract

HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.

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Year:  2005        PMID： 16385008      PMCID： PMC2242465          DOI： 10.1110/ps.051927306

Source DB:  PubMed          Journal:  Protein Sci        ISSN： 0961-8368            Impact factor:   6.725


  25 in total

1.  Point mutations and nucleotide insertions in the MDM2 zinc finger structure of human tumours.

Authors:  T Schlott; S Reimer; A Jahns; A Ohlenbusch; I Ruschenburg; H Nagel; M Droese
Journal:  J Pathol       Date:  1997-05       Impact factor: 7.996

2.  MDMX: a novel p53-binding protein with some functional properties of MDM2.

Authors:  A Shvarts; W T Steegenga; N Riteco; T van Laar; P Dekker; M Bazuine; R C van Ham; W van der Houven van Oordt; G Hateboer; A J van der Eb; A G Jochemsen
Journal:  EMBO J       Date:  1996-10-01       Impact factor: 11.598

Review 3.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

Authors:  S F Altschul; T L Madden; A A Schäffer; J Zhang; Z Zhang; W Miller; D J Lipman
Journal:  Nucleic Acids Res       Date:  1997-09-01       Impact factor: 16.971

4.  The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis.

Authors:  D R Brown; C A Thomas; S P Deb
Journal:  EMBO J       Date:  1998-05-01       Impact factor: 11.598

5.  Protein backbone angle restraints from searching a database for chemical shift and sequence homology.

Authors:  G Cornilescu; F Delaglio; A Bax
Journal:  J Biomol NMR       Date:  1999-03       Impact factor: 2.835

6.  ALSCRIPT: a tool to format multiple sequence alignments.

Authors:  G J Barton
Journal:  Protein Eng       Date:  1993-01

7.  NMRPipe: a multidimensional spectral processing system based on UNIX pipes.

Authors:  F Delaglio; S Grzesiek; G W Vuister; G Zhu; J Pfeifer; A Bax
Journal:  J Biomol NMR       Date:  1995-11       Impact factor: 2.835

Review 8.  Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels.

Authors:  B Miroux; J E Walker
Journal:  J Mol Biol       Date:  1996-07-19       Impact factor: 5.469

9.  In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.

Authors:  Lyubomir T Vassilev; Binh T Vu; Bradford Graves; Daisy Carvajal; Frank Podlaski; Zoran Filipovic; Norman Kong; Ursula Kammlott; Christine Lukacs; Christian Klein; Nader Fotouhi; Emily A Liu
Journal:  Science       Date:  2004-01-02       Impact factor: 47.728

10.  Ubiquitin interactions of NZF zinc fingers.

Authors:  Steven L Alam; Ji Sun; Marielle Payne; Brett D Welch; B Kelly Blake; Darrell R Davis; Hemmo H Meyer; Scott D Emr; Wesley I Sundquist
Journal:  EMBO J       Date:  2004-03-18       Impact factor: 11.598
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  19 in total

1.  Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.

Authors:  Mikael S Lindström; Aiwen Jin; Chad Deisenroth; Gabrielle White Wolf; Yanping Zhang
Journal:  Mol Cell Biol       Date:  2006-11-20       Impact factor: 4.272

2.  Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif.

Authors:  Erin G Worrall; Bartosz Wawrzynow; Liam Worrall; Malcolm Walkinshaw; Kathryn L Ball; Ted R Hupp
Journal:  J Chem Biol       Date:  2009-05-16

3.  Intrinsically unstructured domains of Arf and Hdm2 form bimolecular oligomeric structures in vitro and in vivo.

Authors:  Sivashankar G Sivakolundu; Amanda Nourse; Simon Moshiach; Brian Bothner; Chimere Ashley; John Satumba; Jill Lahti; Richard W Kriwacki
Journal:  J Mol Biol       Date:  2008-09-16       Impact factor: 5.469

4.  MDMX contains an autoinhibitory sequence element.

Authors:  Michal Bista; Miriana Petrovich; Alan R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-14       Impact factor: 11.205

5.  The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors.

Authors:  Christopher Stapf; Edward Cartwright; Mark Bycroft; Kay Hofmann; Alexander Buchberger
Journal:  J Biol Chem       Date:  2011-09-06       Impact factor: 5.157

6.  Autoactivation of the MDM2 E3 ligase by intramolecular interaction.

Authors:  Qian Cheng; Tanjing Song; Lihong Chen; Jiandong Chen
Journal:  Mol Cell Biol       Date:  2014-05-19       Impact factor: 4.272

7.  The evolution of MDM2 family genes.

Authors:  Jamil Momand; Alberto Villegas; Vladimir A Belyi
Journal:  Gene       Date:  2011-07-04       Impact factor: 3.688

8.  The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by Rot dependent and independent pathways.

Authors:  Lotte Jelsbak; Hanne Ingmer; Lukás Valihrach; Marianne Thorup Cohn; Mie H G Christiansen; Birgitte H Kallipolitis; Dorte Frees
Journal:  PLoS One       Date:  2010-09-14       Impact factor: 3.240

9.  Splicing up mdm2 for cancer proteome diversity.

Authors:  Danielle R Okoro; Melissa Rosso; Jill Bargonetti
Journal:  Genes Cancer       Date:  2012-03

Review 10.  Signaling to p53: ribosomal proteins find their way.

Authors:  Yanping Zhang; Hua Lu
Journal:  Cancer Cell       Date:  2009-11-06       Impact factor: 31.743
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