| Literature DB >> 16384705 |
Yang Song1, Ping Wang, Juanjuan Wu, Xiang Zhou, Xiao-Lian Zhang, Linhong Weng, Xiaoping Cao, Feng Liang.
Abstract
Three water-soluble DNA cross-linking phenol quaternary ammonium derivatives 3, 4, and 5 could inhibit the transcription in vitro by photoactivation. DNA interstrand cross-linking action might be the key factor to inhibit transcription by these compounds. Further tumor cell apoptosis was observed by flow cytometry it indicated that cross-linking agent 5 could significantly induce the late apoptosis of tumor cells.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16384705 DOI： 10.1016/j.bmcl.2005.12.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823