| Literature DB >> 16384704 |
Ranjit C Desai1, Edward Metzger, Conrad Santini, Peter T Meinke, James V Heck, Joel P Berger, Karen L MacNaul, Tian-quan Cai, Samuel D Wright, Arun Agrawal, David E Moller, Soumya P Sahoo.
Abstract
Beginning with a moderately potent PPARgamma agonist 9, a series of potent and highly subtype-selective PPARalpha agonists was identified through a systematic SAR study. Based on the results of the efficacy studies in the hamster and dog models of dyslipidemia and the desired pharmacokinetic data, the optimized compound 39 was selected for further profiling.Entities:
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Year: 2005 PMID： 16384704 DOI： 10.1016/j.bmcl.2005.12.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823