Literature DB >> 16384701

Synthesis and biological evaluation of simplified mycothiazole analogues.

Graciela Mahler1, Gloria Serra, Sylvia Dematteis, Jenny Saldaña, Laura Domínguez, Eduardo Manta.   

Abstract

Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L(4) larvae of nematode Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity.

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Year:  2005        PMID： 16384701     DOI： 10.1016/j.bmcl.2005.11.072

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration.

Authors:  Tyler A Johnson; Joseph D Morris; David A Coppage; Colon V Cook; Lauren N Persi; Marcos A Ogarrio; Taylor C Garcia; Nicole L McIntosh; Erin P McCauley; Joseph Media; Mani Maheshwari; Frederick A Valeriote; Jiajiu Shaw; Phillip Crews
Journal:  ACS Med Chem Lett       Date:  2020-01-02       Impact factor: 4.345

2.  Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.

Authors:  Tyler A Johnson; Johann Sohn; Wayne D Inman; Samarkand A Estee; Steven T Loveridge; Helene C Vervoort; Karen Tenney; Junke Liu; Kenny Kean-Hooi Ang; Joseline Ratnam; Walter M Bray; Nadine C Gassner; Young Y Shen; R Scott Lokey; James H McKerrow; Kyria Boundy-Mills; Arif Nukanto; Atit Kanti; Heddy Julistiono; Leonardus B S Kardono; Leonard F Bjeldanes; Phillip Crews
Journal:  J Nat Prod       Date:  2011-11-30       Impact factor: 4.050

3.  The marine sponge metabolite mycothiazole: a novel prototype mitochondrial complex I inhibitor.

Authors:  J Brian Morgan; Fakhri Mahdi; Yang Liu; Veena Coothankandaswamy; Mika B Jekabsons; Tyler A Johnson; Koneni V Sashidhara; Phillip Crews; Dale G Nagle; Yu-Dong Zhou
Journal:  Bioorg Med Chem       Date:  2010-06-25       Impact factor: 3.641

Review 4.  A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.

Authors:  Koneni V Sashidhara; Kimberly N White; Phillip Crews
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050

5.  Toward the Total Synthesis of Scleritodermin A: Preparation of the C(1)-N(15) Fragment.

Authors:  Diver Sellanes; Eduardo Manta; Gloria Serra
Journal:  Tetrahedron Lett       Date:  2007-03-05       Impact factor: 2.415

6.  Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole.

Authors:  Kirsten J Meyer; A Jonathan Singh; Alanna Cameron; An S Tan; Dora C Leahy; David O'Sullivan; Praneta Joshi; Anne C La Flamme; Peter T Northcote; Michael V Berridge; John H Miller
Journal:  Mar Drugs       Date:  2012-04-16       Impact factor: 6.085

7.  Synthesis and Antimicrobial Evaluation of Some New Thiazoline and Thiazolidinone Derivatives Incorporating [1,2,4]Triazolo[1,5-a]benzimidazole.

Authors:  A M Mahmoud; Ola I A Salem; Samia G Abdel Moty; A M Abdel Alim
Journal:  Indian J Pharm Sci       Date:  2013-09       Impact factor: 0.975
  7 in total

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