| Literature DB >> 16384699 |
Sangtae Oh1, In Howa Jeong, Woon-Seob Shin, Qian Wang, Seokjoon Lee.
Abstract
Natural product hedychilactone A (3) has been synthesized from (+)-sclareolide by an efficient route. Two of the synthetic intermediates, 10 and 12, have shown strong growth inhibition effects against five cancer cell lines, human umbilical vein endothelial cell (HUVEC) and nitric oxide (NO) production. In particular, compound 15 showed selective inhibition activity against HUVEC growth without any cytotoxicity among tested cancer cell lines.Entities:
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Year: 2005 PMID： 16384699 DOI： 10.1016/j.bmcl.2005.12.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823