Literature DB >> 16382884

Proliferative senescence in hematopoietic stem cells during ex-vivo expansion.

Wanda Piacibello1, Loretta Gammaitoni, Ymera Pignochino.   

Abstract

The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16382884

Source DB:  PubMed          Journal:  Folia Histochem Cytobiol        ISSN： 0239-8508            Impact factor:   1.698


  5 in total

1.  Foe turned friend: multiple functional roles attributable to hyper-activating stem cell factor receptor mutant in regeneration of the haematopoietic cell compartment.

Authors:  S Pati; O P Kalra; A Mukhopadhyay
Journal:  Cell Prolif       Date:  2011-02       Impact factor: 6.831

Review 2.  Molecular chaperones regulate p53 and suppress senescence programs.

Authors:  Michael Y Sherman; Michael Sherman; Vladimir Gabai; Cornelia O'Callaghan; Julia Yaglom
Journal:  FEBS Lett       Date:  2007-05-25       Impact factor: 4.124

3.  CRISPR/Cas9-Mediated Genome Editing Corrects Dystrophin Mutation in Skeletal Muscle Stem Cells in a Mouse Model of Muscle Dystrophy.

Authors:  Pei Zhu; Furen Wu; Jeffrey Mosenson; Hongmei Zhang; Tong-Chuan He; Wen-Shu Wu
Journal:  Mol Ther Nucleic Acids       Date:  2017-02-28

Review 4.  Toward personalized cell therapies by using stem cells: seven relevant topics for safety and success in stem cell therapy.

Authors:  Fernando de Sá Silva; Paula Nascimento Almeida; João Vitor Paes Rettore; Claudinéia Pereira Maranduba; Camila Maurmann de Souza; Gustavo Torres de Souza; Rafaella de Souza Salomão Zanette; Sueli Patricia Harumi Miyagi; Marcelo de Oliveira Santos; Márcia Martins Marques; Carlos Magno da Costa Maranduba
Journal:  J Biomed Biotechnol       Date:  2012-11-20

5.  Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives.

Authors:  Senthilkumar Preethy; Sudhakar John; Jegatheesan Saravana Ganesh; Thangavelu Srinivasan; Hiroshi Terunuma; Masaru Iwasaki; Samuel J Abraham
Journal:  Stem Cells Cloning       Date:  2013-04-04
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.