Literature DB >> 16382187

The serotonergic system and its role in cocaine addiction.

Małgorzata Filip1, Małgorzata Frankowska, Magdalena Zaniewska, Anna Gołda, Edmund Przegaliński.   

Abstract

Cocaine is an alkaloid with psychostimulant action and high addictive potential. It possesses high affinity for the transporters of dopamine, serotonin (5-HT) and noradrenaline, and blocks reuptake of the above-mentioned monoamines. The present review summarized the contribution of 5-HT neurotransmitter system to rewarding and aversive properties of cocaine, to cocaine withdrawal and its long-term abuse. The present state of knowledge of 5-HT neurotransmission justifies the opinion that pharmacological manipulation in the 5-HT system may efficiently counteract the effects of cocaine withdrawal and prevent reinstatement of its abuse.

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Year:  2005        PMID： 16382187

Source DB:  PubMed          Journal:  Pharmacol Rep        ISSN： 1734-1140            Impact factor:   3.024


  32 in total

Review 1.  Novel pharmacotherapeutic treatments for cocaine addiction.

Authors:  Daryl Shorter; Thomas R Kosten
Journal:  BMC Med       Date:  2011-11-03       Impact factor: 8.775

2.  The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats.

Authors:  Jennifer M Wenzel; Zu-In Su; Kerisa Shelton; Hiram M Dominguez; Victoria A von Furstenberg; Aaron Ettenberg
Journal:  Pharmacol Biochem Behav       Date:  2013-09-05       Impact factor: 3.533

3.  The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats.

Authors:  Andre Der-Avakian; Sondra T Bland; Robert R Rozeske; Julie P Tamblyn; Mark R Hutchinson; Linda R Watkins; Steven F Maier
Journal:  Psychopharmacology (Berl)       Date:  2007-01-09       Impact factor: 4.530

4.  Anxiolytic-like actions of buspirone in a runway model of intravenous cocaine self-administration.

Authors:  Aaron Ettenberg; Rick E Bernardi
Journal:  Pharmacol Biochem Behav       Date:  2006-10-24       Impact factor: 3.533

5.  Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms.

Authors:  Alison Oliveto; James Poling; Michael J Mancino; D Keith Williams; Jeff Thostenson; Rhonda Pruzinsky; Kishorchandra Gonsai; Mehmet Sofuoglu; Gerardo Gonzalez; Shanti Tripathi; Thomas R Kosten
Journal:  Addiction       Date:  2011-10-10       Impact factor: 6.526

6.  Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine.

Authors:  Vicky Katsidoni; Kalliopi Apazoglou; George Panagis
Journal:  Psychopharmacology (Berl)       Date:  2010-06-25       Impact factor: 4.530

7.  Social stress and the polymorphic region of the serotonin reuptake transporter gene modify oestradiol-induced changes on central monoamine concentrations in female rhesus monkeys.

Authors:  J Asher; V Michopoulos; K M Reding; M E Wilson; D Toufexis
Journal:  J Neuroendocrinol       Date:  2013-04       Impact factor: 3.627

8.  Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors.

Authors:  P K Thanos; C Bermeo; M Rubinstein; K L Suchland; G J Wang; D K Grandy; N D Volkow
Journal:  J Psychopharmacol       Date:  2009-03-12       Impact factor: 4.153

9.  5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking.

Authors:  In-Jee You; Sherie R Wright; Alvaro L Garcia-Garcia; Andrew R Tapper; Paul D Gardner; George F Koob; E David Leonardo; Laura M Bohn; Sunmee Wee
Journal:  Neuropsychopharmacology       Date:  2015-09-01       Impact factor: 7.853

10.  Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid-base properties.

Authors:  Agnieszka Zagórska; Anna Czopek; Maciej Pawłowski; Małgorzata Dybała; Agata Siwek; Gabriel Nowak
Journal:  Med Chem Res       Date:  2011-11-19       Impact factor: 1.965
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