Literature DB >> 16382046

Regulation of cancer cell survival by Par-4.

Padhma Ranganathan1, Vivek M Rangnekar.   

Abstract

Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par-4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.

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Year:  2005        PMID： 16382046     DOI： 10.1196/annals.1339.046

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  16 in total

Review 1.  PAR-4 as a possible new target for pancreatic cancer therapy.

Authors:  Asfar S Azmi; Philip A Philip; Syed F Zafar; Fazlul H Sarkar; Ramzi M Mohammad
Journal:  Expert Opin Ther Targets       Date:  2010-06       Impact factor: 6.902

2.  Expression Pattern of the Pro-apoptotic Gene PAR-4 During the Morphogenesis of MCF-10A Human Mammary Epithelial Cells.

Authors:  Simone A de Bessa Garcia; Michelly C Pereira; Maria A Nagai
Journal:  Cancer Microenviron       Date:  2010-12-21

3.  Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.

Authors:  Bi-Dar Wang; Christina Leah B Kline; Danielle M Pastor; Thomas L Olson; Bryan Frank; Truong Luu; Arun K Sharma; Gavin Robertson; Matthew T Weirauch; Steven R Patierno; Joshua M Stuart; Rosalyn B Irby; Norman H Lee
Journal:  Mol Cancer       Date:  2010-04-30       Impact factor: 27.401

4.  Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.

Authors:  X Chen; A A Sahasrabuddhe; P Szankasi; F Chung; V Basrur; V M Rangnekar; M Pagano; M S Lim; K S J Elenitoba-Johnson
Journal:  Cell Death Differ       Date:  2014-07-04       Impact factor: 15.828

5.  Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.

Authors:  James V Alvarez; Tien-Chi Pan; Jason Ruth; Yi Feng; Alice Zhou; Dhruv Pant; Joshua S Grimley; Thomas J Wandless; Angela Demichele; Lewis A Chodosh
Journal:  Cancer Cell       Date:  2013-06-13       Impact factor: 31.743

6.  The complexity of signaling in host-pathogen interactions revealed by the Toxoplasma gondii-dependent modulation of JNK phosphorylation.

Authors:  John C Carmen; R Chase Southard; Anthony P Sinai
Journal:  Exp Cell Res       Date:  2008-10-07       Impact factor: 3.905

Review 7.  Apoptosis and tumor resistance conferred by Par-4.

Authors:  Yanming Zhao; Vivek M Rangnekar
Journal:  Cancer Biol Ther       Date:  2008-12-08       Impact factor: 4.742

Review 8.  Role of p38 MAP Kinase Signal Transduction in Solid Tumors.

Authors:  Hari K Koul; Mantu Pal; Sweaty Koul
Journal:  Genes Cancer       Date:  2013-09

9.  Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia.

Authors:  Mary K McKenna; Sunil K Noothi; Sara S Alhakeem; Karine Z Oben; Joseph T Greene; Rajeswaran Mani; Kathryn L Perry; James P Collard; Jacqueline R Rivas; Gerhard C Hildebrandt; Roger A Fleischman; Eric B Durbin; John C Byrd; Chi Wang; Natarajan Muthusamy; Vivek M Rangnekar; Subbarao Bondada
Journal:  Blood       Date:  2018-04-25       Impact factor: 22.113

10.  Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells.

Authors:  Moulinath Acharya; David J Lingenfelter; Lijia Huang; Philip J Gage; Michael A Walter
Journal:  J Biol Chem       Date:  2009-10-02       Impact factor: 5.157
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