Literature DB >> 16381680

Implications of the space radiation environment for human exploration in deep space.

Lawrence W Townsend1.   

Abstract

Human exploration of the solar system beyond Earth's orbit will entail many risks for the crew on these deep space missions. One of the most significant health risks is exposure to the harsh space radiation environment beyond the protection provided by the Earth's intrinsic magnetic field. Crew on exploration missions will be exposed to a complex mixture of very energetic particles. Chronic exposures to the ever-present background galactic cosmic ray (GCR) spectrum consisting of all naturally occurring chemical elements are combined with sporadic, possibly acute exposures to large fluxes of solar energetic particles, mainly protons and alpha particles. The background GCR environment is mainly a matter of concern for stochastic effects, such as the induction of cancer with subsequent mortality in many cases, and late deterministic effects, such as cataracts and possible damage to the central nervous system. Unfortunately, the actual risks of cancer induction and mortality owing to the very important high-energy heavy ion component of the GCR spectrum are essentially unknown. The sporadic occurrence of extremely large solar energetic particle events (SPE), usually associated with intense solar activity, is also a major concern for the possible manifestation of acute effects from the accompanying high doses of such radiations, especially acute radiation syndrome effects such as nausea, emesis, haemorrhaging or, possibly, even death. In this presentation, an overview of the space radiation environment, estimates of the associated body organ doses and equivalent doses and the potential biological effects on crew in deep space are presented. Possible methods of mitigating these radiations, thereby reducing the associated risks to crew are also described.

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Mesh:

Year:  2005        PMID: 16381680     DOI: 10.1093/rpd/nci141

Source DB:  PubMed          Journal:  Radiat Prot Dosimetry        ISSN: 0144-8420            Impact factor:   0.972


  35 in total

1.  Effects of Solar Particle Event-Like Proton Radiation and/or Simulated Microgravity on Circulating Mouse Blood Cells.

Authors:  Ana L Romero-Weaver; Liyong Lin; Alejandro Carabe-Fernandez; Ann R Kennedy
Journal:  Gravit Space Res       Date:  2014-08

2.  Orally Administered Fructose Increases the Numbers of Peripheral Lymphocytes Reduced by Exposure of Mice to Gamma or SPE-like Proton Radiation.

Authors:  A L Romero-Weaver; J Ni; L Lin; A R Kennedy
Journal:  Life Sci Space Res (Amst)       Date:  2014-07

3.  Different Sequences of Fractionated Low-Dose Proton and Single Iron-Radiation-Induced Divergent Biological Responses in the Heart.

Authors:  Sharath P Sasi; Xinhua Yan; Marian Zuriaga-Herrero; Hannah Gee; Juyong Lee; Raman Mehrzad; Jin Song; Jillian Onufrak; James Morgan; Heiko Enderling; Kenneth Walsh; Raj Kishore; David A Goukassian
Journal:  Radiat Res       Date:  2017-06-14       Impact factor: 2.841

4.  Effects of a granulocyte colony stimulating factor, Neulasta, in mini pigs exposed to total body proton irradiation.

Authors:  Jenine K Sanzari; Gabriel S Krigsfeld; Anne L Shuman; Antonia K Diener; Liyong Lin; Wilfried Mai; Ann R Kennedy
Journal:  Life Sci Space Res (Amst)       Date:  2015-04

5.  Mechanism of hypocoagulability in proton-irradiated ferrets.

Authors:  Gabriel S Krigsfeld; Alexandria R Savage; Jenine K Sanzari; Andrew J Wroe; Daila S Gridley; Ann R Kennedy
Journal:  Int J Radiat Biol       Date:  2013-06-10       Impact factor: 2.694

6.  Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice.

Authors:  Jianhui Chang; Wei Feng; Yingying Wang; Yi Luo; Antiño R Allen; Igor Koturbash; Jennifer Turner; Blair Stewart; Jacob Raber; Martin Hauer-Jensen; Daohong Zhou; Lijian Shao
Journal:  Radiat Res       Date:  2015-01-30       Impact factor: 2.841

7.  Biological Effects of Space Radiation and Development of Effective Countermeasures.

Authors:  Ann R Kennedy
Journal:  Life Sci Space Res (Amst)       Date:  2014-04-01

Review 8.  Behavioral effects of space radiation: A comprehensive review of animal studies.

Authors:  Frederico Kiffer; Marjan Boerma; Antiño Allen
Journal:  Life Sci Space Res (Amst)       Date:  2019-02-19

9.  Oxidative Lung Damage Resulting from Repeated Exposure to Radiation and Hyperoxia Associated with Space Exploration.

Authors:  Ralph A Pietrofesa; Jason B Turowski; Evguenia Arguiri; Tatyana N Milovanova; Charalambos C Solomides; Stephen R Thom; Melpo Christofidou-Solomidou
Journal:  J Pulm Respir Med       Date:  2013-09-30

10.  Dermatopathology effects of simulated solar particle event radiation exposure in the porcine model.

Authors:  Jenine K Sanzari; Eric S Diffenderfer; Sarah Hagan; Paul C Billings; Daila S Gridley; John T Seykora; Ann R Kennedy; Keith A Cengel
Journal:  Life Sci Space Res (Amst)       Date:  2015-06-18
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