| Literature DB >> 16381556 |
T Robert Wu1, J Michael Chong.
Abstract
[reaction: see text] Alkynylboronates derived from 3,3'-disubstituted-2,2'-binaphthols react with various N-acylimines to give the expected chiral propargylamides with up to 99% ee. This new methodology was applied to the first enantioselective synthesis of the antitubulin agent (-)-N-acetylcolchinol.Entities:
Year: 2006 PMID： 16381556 DOI： 10.1021/ol0523087
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005