| Literature DB >> 16380255 |
Andreas Wållberg1, Karolina Nilsson, Krister Osterlund, Alecia Peterson, Susanne Elg, Patrick Raboisson, Udo Bauer, Lance G Hammerland, Jan P Mattsson.
Abstract
Fenobam (1) was developed by McNeil Laboratories as an anxiolytic agent with an unknown molecular target in the late 1970s. In a recent publication, it was revealed that fenobam is a non-competitive mGluR5 antagonist. Herein, we present the structure-activity relationship of fenobam and its analogues and similarities between the SAR of mGluR5 antagonism and the SAR of CNS properties originally reported by McNeil are discussed.Entities:
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Year: 2005 PMID： 16380255 DOI： 10.1016/j.bmcl.2005.11.092
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823