| Literature DB >> 16380252 |
Subas M Sakya1, Hengmiao Cheng, Kristin M Lundy Demello, Andrei Shavnya, Martha L Minich, Bryson Rast, Jason Dutra, Chao Li, Robert J Rafka, David A Koss, Jin Li, Burton H Jaynes, Carl B Ziegler, Donald W Mann, Carol F Petras, Scott B Seibel, Annette M Silvia, David M George, Anne Hickman, Michelle L Haven, Michael P Lynch.
Abstract
Structure-activity relationship (SAR) studies of novel 2-[3-trifluoromethyl-5-alkyl(thio)ether pyrazo-1-yl]-5-methanesulfonyl pyridine derivatives for canine COX enzymes are described. The 4-cyano-5-alkyl ethers were found to have excellent potency and selectivity, whereas the 5-thioethers were potent but less selective than the ether analogs in a canine whole blood (CWB) COX-2 assay.Entities:
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Year: 2005 PMID： 16380252 DOI： 10.1016/j.bmcl.2005.11.110
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823