| Literature DB >> 16380250 |
Tsuyoshi Shinozuka1, Kousei Shimada, Satoshi Matsui, Takahiro Yamane, Mayumi Ama, Takeshi Fukuda, Motohiko Taki, Satoru Naito.
Abstract
We have designed and synthesized a novel series of 3-biphenylamino acid amides as cathepsin K inhibitors based on compound I. In these inhibitors, we have discovered 4-aminophenoxyacetic acids 43 and 47 with good IC(50) values, although lipophilic groups are favorable for the hydrophobic S1' pocket.Entities:
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Year: 2005 PMID： 16380250 DOI： 10.1016/j.bmcl.2005.12.053
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823