| Literature DB >> 16378687 |
G He1, J Zhang, X W Li, W Y Chen, Y X Pan, F P Yang, N F Gu, G Y Feng, S L Yang, J Y He, B X Liu, Y W Peng, J Liu, L He.
Abstract
The interleukin-10 (IL-10) gene has been identified as a susceptibility gene for schizophrenia in Caucasians. A previous case-control study conducted by our group revealed a weak association between polymorphism, -592C/A, of the IL-10 gene promoter and schizophrenia. Our present study was aimed at confirming the association of the IL-10 promoter with schizophrenia using 197 Han Chinese sib-pair families. A family-based association test (FBAT) and haplotype analysis was undertaken using the FBAT v1.5.5. The global TDT was significant for a different polymorphism, -1082G/A (chi2=13.16, P=0.000285) and that the allele -1082G was preferentially transmitted to schizophrenia-affected children. Furthermore, haplotype TDT analysis showed that haplotype "GCC" was significantly associated with the disease (chi2=8.1, P=0.00443). Our results also indicate that the IL-10 gene may play a significant role in the etiology of schizophrenia among Han Chinese.Entities:
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Year: 2005 PMID： 16378687 DOI： 10.1016/j.neulet.2005.06.054
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046