| Literature DB >> 16378489 |
Pierre Van de Weghe1, Jacques Eustache.
Abstract
Recent developments of the metathesis reaction in the area of biologically active molecules are presented. Scope and limitations of ring-closing metathesis to form medium and large rings are discussed and illustrated by the epothilone synthesis. Applications of the metathesis reaction related to medicinal chemistry, including solid phase synthesis and combinatorial chemistry are presented.Entities:
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Year: 2005 PMID： 16378489 DOI： 10.2174/156802605775009748
Source DB: PubMed Journal: Curr Top Med Chem ISSN： 1568-0266 Impact factor: 3.295