Literature DB >> 16378374

Bis(bibenzyls) from liverworts inhibit lipopolysaccharide-induced inducible NOS in RAW 264.7 cells: a study of structure-activity relationships and molecular mechanism.

Liva Harinantenaina1, Dang Ngoc Quang, Nishizawa Takeshi, Toshihiro Hashimoto, Chie Kohchi, Gen-Ichiro Soma, Yoshinori Asakawa.   

Abstract

The inhibition of lipopolysaccharide-induced NOS by 19 bis(bibenzyls) isolated from liverworts in RAW 264.7 macrophages was evaluated. The presence of phenolic hydroxyls and saturation at 7,8 and/or 7'/8' are required for inhibition of NO production. Among the compounds tested, marchantin A was the most potent, and its inhibitory activity was consistent with the inhibition of LPS-induced iNOS mRNA.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16378374     DOI： 10.1021/np0502589

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  5 in total

1.  In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei.

Authors:  Kazuhiko Otoguro; Aki Ishiyama; Masato Iwatsuki; Miyuki Namatame; Aki Nishihara-Tukashima; Hiroaki Kiyohara; Toshihiro Hashimoto; Yoshinori Asakawa; Satoshi Omura; Haruki Yamada
Journal:  J Nat Med       Date:  2011-09-16       Impact factor: 2.343

2.  Ring strain and total syntheses of modified macrocycles of the isoplagiochin type.

Authors:  Andreas Speicher; Timo Backes; Kerstin Hesidens; Jürgen Kolz
Journal:  Beilstein J Org Chem       Date:  2009-12-01       Impact factor: 2.883

3.  RECENT SYNTHETIC DEVELOPMENTS AND APPLICATIONS OF THE ULLMANN REACTION. A REVIEW.

Authors:  Hao Lin; Dianqing Sun
Journal:  Org Prep Proced Int       Date:  2013       Impact factor: 1.628

4.  Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.

Authors:  Yuma Iwai; Kouki Murakami; Yasuyuki Gomi; Toshihiro Hashimoto; Yoshinori Asakawa; Yoshinobu Okuno; Toyokazu Ishikawa; Dai Hatakeyama; Noriko Echigo; Takashi Kuzuhara
Journal:  PLoS One       Date:  2011-05-20       Impact factor: 3.240

Review 5.  Bibenzyls and bisbybenzyls of bryophytic origin as promising source of novel therapeutics: pharmacology, synthesis and structure-activity.

Authors:  Samapika Nandy; Abhijit Dey
Journal:  Daru       Date:  2020-08-15       Impact factor: 3.117
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.