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Literature DB >> 1637803

Sodium valproate and clonazepam for treatment-resistant panic disorder.

Abstract

Sodium valproate (VA) and clonazepam (CLZ) were combined in the treatment of 4 patients with panic disorders (PD) who were resistant to several antipanic drug treatments. A significant improvement was found in the symptomatology of these patients, but relapses occurred when CLZ dosage was reduced. A potentiation of the GABAergic properties of VA and clonazepam is postulated. This combined treatment could be advantageous for some treatment-resistant PD patients but needs to be studied further.

Entities: Chemical Disease Species

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Year: 1992 PMID： 1637803 PMCID： PMC1188405

Source DB: PubMed Journal: J Psychiatry Neurosci ISSN： 1180-4882 Impact factor: 6.186

12 in total

1. An analysis of the kinetics of the inhibition of rabbit brain gamma-aminobutyrate aminotransferase by sodium n-dipropylacetate and some other simple carboxylic acids.

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Journal: Biochem Pharmacol Date: 1975-07-15 Impact factor: 5.858

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Journal: Biol Psychiatry Date: 1988-12 Impact factor: 13.382

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Authors: R Noyes; M J Garvey; B L Cook; L Samuelson
Journal: J Clin Psychiatry Date: 1989-05 Impact factor: 4.384

Review 4. Valproate: an updated review.

Authors: L Gram; K D Bentsen
Journal: Acta Neurol Scand Date: 1985-08 Impact factor: 3.209

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Authors: R Noyes; J Reich; J Christiansen; M Suelzer; B Pfohl; W A Coryell
Journal: Arch Gen Psychiatry Date: 1990-09

6. Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. II. Patient acceptance, side effects, and safety.

Authors: R Noyes; R L DuPont; J C Pecknold; A Rifkin; R T Rubin; R P Swinson; J C Ballenger; G D Burrows
Journal: Arch Gen Psychiatry Date: 1988-05

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Authors: C M Zitrin; D F Klein; M G Woerner; D C Ross
Journal: Arch Gen Psychiatry Date: 1983-02

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Authors: A P Levin; M R Liebowitz
Journal: Drugs Date: 1987-10 Impact factor: 9.546

9. Effect of convulsant and anticonvulsant agents on level and metabolism of gamma-aminobutyric acid in mouse brain.

Authors: W Löscher; H H Frey
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-02 Impact factor: 3.000

10. Effect of valproic acid on [3H]diazepam and [3H]dihydropicrotoxinin binding sites at the benzodiazepine-GABA receptor-ionophore complex.

Authors: M K Ticku; W C Davis
Journal: Brain Res Date: 1981-10-26 Impact factor: 3.252

7 in total

Sodium valproate and clonazepam for treatment-resistant panic disorder.

1. An analysis of the kinetics of the inhibition of rabbit brain gamma-aminobutyrate aminotransferase by sodium n-dipropylacetate and some other simple carboxylic acids.

2. Methylene blue in mania.

3. Problems with tricyclic antidepressant use in patients with panic disorder or agoraphobia: results of a naturalistic follow-up study.

Review 4. Valproate: an updated review.

5. Outcome of panic disorder. Relationship to diagnostic subtypes and comorbidity.

6. Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. II. Patient acceptance, side effects, and safety.

7. Treatment of phobias. I. Comparison of imipramine hydrochloride and placebo.

8. Drug treatment of phobias. Efficacy and optimum use.

9. Effect of convulsant and anticonvulsant agents on level and metabolism of gamma-aminobutyric acid in mouse brain.

10. Effect of valproic acid on [3H]diazepam and [3H]dihydropicrotoxinin binding sites at the benzodiazepine-GABA receptor-ionophore complex.

Review 1. Neurochemical and metabolic aspects of antidepressants: an overview.

Review 2. The Black Book of Psychotropic Dosing and Monitoring.

Review 3. Anticonvulsants in anxiety disorders.

4. Management of treatment-resistant panic disorder.

5. Anxiety Disorders in Neurologic Illness.

Review 6. Antiepileptic drugs in the treatment of anxiety disorders: role in therapy.

Review 7. Anticonvulsant and antipsychotic medications in the pharmacotherapy of panic disorder: a structured review.