Literature DB >> 16377721

Dexamethasone attenuates staphylococcal enterotoxin B-induced hypothermic response and protects mice from superantigen-induced toxic shock.

Teresa Krakauer1, Marilyn Buckley.   

Abstract

The superantigenic staphylococcal enterotoxins are important virulence factors and contribute to various diseases, including food poisoning and toxic shock. Dexamethasone, an anti-inflammatory agent, attenuated staphylococcal enterotoxin B (SEB)-induced hypothermia and serum proinflammatory cytokines and improved survival from 0% to 86% in a lethal mouse model of SEB-mediated shock.

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Year:  2006        PMID： 16377721      PMCID： PMC1346818          DOI： 10.1128/AAC.50.1.391-395.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

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Authors:  G Arad; R Levy; D Hillman; R Kaempfer
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Review 3.  Toxic shock syndrome and bacterial superantigens: an update.

Authors:  J K McCormick; J M Yarwood; P M Schlievert
Journal:  Annu Rev Microbiol       Date:  2001       Impact factor: 15.500

4.  Superantigen and endotoxin synergize in the induction of lethal shock.

Authors:  C Blank; A Luz; S Bendigs; A Erdmann; H Wagner; K Heeg
Journal:  Eur J Immunol       Date:  1997-04       Impact factor: 5.532

5.  A double-blind study of the effectiveness of cortisol in the management of severe infections.

Authors:  I L BENNETT; M FINLAND; M HAMBURGER; E H KASS; M LEPPER; B A WAISBREN
Journal:  Trans Assoc Am Physicians       Date:  1962

6.  Staphylococcal enterotoxin A-induced fever is associated with increased circulating levels of cytokines in rabbits.

Authors:  W T Huang; M T Lin; S J Won
Journal:  Infect Immun       Date:  1997-07       Impact factor: 3.441

7.  Staphylococcal enterotoxin B-induced acute inflammation is inhibited by dexamethasone: important role of CXC chemokines KC and macrophage inflammatory protein 2.

Authors:  Rene Schramm; Henrik Thorlacius
Journal:  Infect Immun       Date:  2003-05       Impact factor: 3.441

Review 8.  Targets of glucocorticoid action on TNF-alpha release by macrophages.

Authors:  D A Joyce; G Gimblett; J H Steer
Journal:  Inflamm Res       Date:  2001-07       Impact factor: 4.575

Review 9.  Chemotherapeutics targeting immune activation by staphylococcal superantigens.

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Journal:  Med Sci Monit       Date:  2005-08-26

10.  Correlation of temperature and toxicity in murine studies of staphylococcal enterotoxins and toxic shock syndrome toxin 1.

Authors:  B G Stiles; Y G Campbell; R M Castle; S A Grove
Journal:  Infect Immun       Date:  1999-03       Impact factor: 3.441
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  23 in total

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4.  Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2.

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Review 5.  Antibodies for biodefense.

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6.  Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology.

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8.  Rapamycin protects mice from staphylococcal enterotoxin B-induced toxic shock and blocks cytokine release in vitro and in vivo.

Authors:  Teresa Krakauer; Marilyn Buckley; Haleem J Issaq; Stephen D Fox
Journal:  Antimicrob Agents Chemother       Date:  2010-01-19       Impact factor: 5.191

9.  Proinflammatory mediators of toxic shock and their correlation to lethality.

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10.  Genome Expression Profiling-Based Identification and Administration Efficacy of Host-Directed Antimicrobial Drugs against Respiratory Infection by Nontypeable Haemophilus influenzae.

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