Literature DB >> 16377719

Different modes of action of naphthyridones in gram-positive and gram-negative bacteria.

Ed T Buurman1, Kenneth D Johnson, Roxanne K Kelly, Kathy MacCormack.   

Abstract

Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli. These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.

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Year:  2006        PMID： 16377719      PMCID： PMC1346805          DOI： 10.1128/AAC.50.1.385-387.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

Authors:  M Pioletti; F Schlünzen; J Harms; R Zarivach; M Glühmann; H Avila; A Bashan; H Bartels; T Auerbach; C Jacobi; T Hartsch; A Yonath; F Franceschi
Journal:  EMBO J       Date:  2001-04-17       Impact factor: 11.598

2.  Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA.

Authors:  Ditlev E Brodersen; William M Clemons; Andrew P Carter; Brian T Wimberly; V Ramakrishnan
Journal:  J Mol Biol       Date:  2002-02-22       Impact factor: 5.469

3.  Mechanism of action of a novel series of naphthyridine-type ribosome inhibitors: enhancement of tRNA footprinting at the decoding site of 16S rRNA.

Authors:  Linus L Shen; Candace Black-Schaefer; Yingna Cai; Peter J Dandliker; Bruce A Beutel
Journal:  Antimicrob Agents Chemother       Date:  2005-05       Impact factor: 5.191

4.  Tryptic fragments of the Escherichia coli DNA gyrase A protein.

Authors:  R J Reece; A Maxwell
Journal:  J Biol Chem       Date:  1989-11-25       Impact factor: 5.157

5.  Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

Authors:  H Yoshida; M Bogaki; M Nakamura; S Nakamura
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

6.  Quinolone-resistant Haemophilus influenzae in a long-term-care facility: nucleotide sequence characterization of alterations in the genes encoding DNA gyrase and DNA topoisomerase IV.

Authors:  Xinying Li; Noriel Mariano; James J Rahal; Carl M Urban; Karl Drlica
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

7.  Topoisomerase IV is a target of quinolones in Escherichia coli.

Authors:  A B Khodursky; E L Zechiedrich; N R Cozzarelli
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205

8.  Novel antibacterial class.

Authors:  Peter J Dandliker; Steve D Pratt; Angela M Nilius; Candace Black-Schaefer; Xiaoan Ruan; Danli L Towne; Richard F Clark; Erika E Englund; Rolf Wagner; Moshe Weitzberg; Linda E Chovan; Robert K Hickman; Melissa M Daly; Stephan Kakavas; Ping Zhong; Zhensheng Cao; Caroline A David; Xiaoling Xuei; Claude G Lerner; Niru B Soni; Mai Bui; Linus L Shen; Yingna Cai; Philip J Merta; Anne Y C Saiki; Bruce A Beutel
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

9.  Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; T Itoh; J I Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

10.  Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.

Authors:  Xiaolei Yu; Milorad Susa; Cornelius Knabbe; Rolf D Schmid; Till T Bachmann
Journal:  J Clin Microbiol       Date:  2004-09       Impact factor: 5.948
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  7 in total

1.  In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae.

Authors:  Ed T Buurman; Beth Andrews; Ning Gao; Jun Hu; Thomas A Keating; Sushmita Lahiri; Ludovic R Otterbein; Arthur D Patten; Suzanne S Stokes; Adam B Shapiro
Journal:  J Biol Chem       Date:  2011-10-07       Impact factor: 5.157

2.  Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.

Authors:  Scott D Mills; Ann E Eakin; Ed T Buurman; Joseph V Newman; Ning Gao; Hoan Huynh; Kenneth D Johnson; Sushmita Lahiri; Adam B Shapiro; Grant K Walkup; Wei Yang; Suzanne S Stokes
Journal:  Antimicrob Agents Chemother       Date:  2010-12-28       Impact factor: 5.191

3.  A novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteria.

Authors:  Jun Fan; Boudewijn L M de Jonge; Kathy MacCormack; Shubha Sriram; Robert E McLaughlin; Helen Plant; Marian Preston; Paul R Fleming; Robert Albert; Melinda Foulk; Scott D Mills
Journal:  Antimicrob Agents Chemother       Date:  2014-09-22       Impact factor: 5.191

4.  Small-molecule inhibitors of gram-negative lipoprotein trafficking discovered by phenotypic screening.

Authors:  Sarah M McLeod; Paul R Fleming; Kathleen MacCormack; Robert E McLaughlin; James D Whiteaker; Shin-Ichiro Narita; Makiko Mori; Hajime Tokuda; Alita A Miller
Journal:  J Bacteriol       Date:  2015-01-12       Impact factor: 3.490

5.  Antimicrobial Activity of Adenine-Based Inhibitors of NAD(+)-Dependent DNA Ligase.

Authors:  Ed T Buurman; Valerie A Laganas; Ce Feng Liu; John I Manchester
Journal:  ACS Med Chem Lett       Date:  2012-07-12       Impact factor: 4.345

6.  The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.

Authors:  Ayome Abibi; Andrew D Ferguson; Paul R Fleming; Ning Gao; Laurel I Hajec; Jun Hu; Valerie A Laganas; David C McKinney; Sarah M McLeod; D Bryan Prince; Adam B Shapiro; Ed T Buurman
Journal:  J Biol Chem       Date:  2014-06-16       Impact factor: 5.157

7.  Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.

Authors:  Ed T Buurman; Melinda A Foulk; Ning Gao; Valerie A Laganas; David C McKinney; Demetri T Moustakas; Jonathan A Rose; Adam B Shapiro; Paul R Fleming
Journal:  J Bacteriol       Date:  2012-07-27       Impact factor: 3.490
  7 in total

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