| Literature DB >> 16377556 |
Ralph A W Rupp1, Peter B Becker.
Abstract
Linker histones of the H1 family are among the most abundant components of chromatin. In this issue of Cell, the effect of H1 downregulation on gene expression is examined. Although a 50% reduction of histone H1 levels in embryonic stem cells affects chromatin structure globally, the expression of very few genes is altered. Intriguingly, this study reveals a new link between H1 and DNA methylation.Mesh：
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Year: 2005 PMID： 16377556 DOI： 10.1016/j.cell.2005.12.004
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582