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Literature DB >> 16377554

Genetics in the age of systems biology.

Peter Robin Hiesinger¹, Bassem A Hassan.

Abstract

Systems biology has become a fashionable label for a new generation of large-scale experiments. This essay explores how classical approaches such as forward genetics fit into this emerging framework.

Mesh：

Year: 2005 PMID： 16377554 DOI： 10.1016/j.cell.2005.12.006

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

8 in total

1. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen.

Authors: Oaz Nir; Chris Bakal; Norbert Perrimon; Bonnie Berger
Journal: Genome Res Date: 2010-02-09 Impact factor: 9.043

Review 2. Commonalities in Biological Pathways, Genetics, and Cellular Mechanism between Alzheimer Disease and Other Neurodegenerative Diseases: An In Silico-Updated Overview.

Authors: Khurshid Ahmad; Mohammad Hassan Baig; Gohar Mushtaq; Mohammad Amjad Kamal; Nigel H Greig; Inho Choi
Journal: Curr Alzheimer Res Date: 2017 Impact factor: 3.498

3. Cancer initiation and progression: an unsimplifiable complexity.

Authors: Fabio Grizzi; Antonio Di Ieva; Carlo Russo; Eldo E Frezza; Everardo Cobos; Pier Carlo Muzzio; Maurizio Chiriva-Internati
Journal: Theor Biol Med Model Date: 2006-10-17 Impact factor: 2.432

Review 4. Identification of Biomarkers in Neuropsychiatric Disorders Based on Systems Biology and Epigenetics.

Authors: Jacob Peedicayil
Journal: Front Genet Date: 2019-10-11 Impact factor: 4.599

5. Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements.

Authors: Wei Jiang; Xia Li; Shaoqi Rao; Lihong Wang; Lei Du; Chuanxing Li; Chao Wu; Hongzhi Wang; Yadong Wang; Baofeng Yang
Journal: BMC Syst Biol Date: 2008-08-10

Genetics in the age of systems biology.

1. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen.

Review 2. Commonalities in Biological Pathways, Genetics, and Cellular Mechanism between Alzheimer Disease and Other Neurodegenerative Diseases: An In Silico-Updated Overview.

3. Cancer initiation and progression: an unsimplifiable complexity.

Review 4. Identification of Biomarkers in Neuropsychiatric Disorders Based on Systems Biology and Epigenetics.

5. Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements.

6. Integrating computational biology and forward genetics in Drosophila.

Review 7. Understanding quantitative genetics in the systems biology era.

8. A computational analysis of protein-protein interaction networks in neurodegenerative diseases.