| Literature DB >> 16377194 |
Haridas Rode1, Stefanie Koerbe, Anita Besch, Karen Methling, Jutta Loose, Hans-Hartwig Otto.
Abstract
Pseudosaccharinamine derivatives were evaluated for elastase inhibitory activity. Ester derivatives of pseudosaccharinamine displayed reversible and high inhibition of human leukocyte elastase (HLE) as compared to porcine pancreatic elastase (PPE). Cyanomethyl (2S,3S)-2-(1,1-dioxobenzo[d]isothiazol-3-ylamino)-3-methylpentanoate was found to inhibit HLE at Ki=0.8 microM.Entities:
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Year: 2005 PMID： 16377194 DOI： 10.1016/j.bmc.2005.11.057
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641