| Literature DB >> 16377080 |
Sérgio Britto Garcia1, Luane Taísa da Costa Barros, Aline Turatti, Flávia Martinello, Patrícia Modiano, Alfredo Ribeiro-Silva, Marcelo Vinícius de Oliveira Vespúcio, Sérgio Akira Uyemura.
Abstract
Orlistat is an anti-obesity agent that increases the fecal fat excretion, which promotes colon carcinogenesis. Therefore, the present study was designed to verify the effects of Orlistat on the formation of rat colonic aberrant crypt foci (ACF) and cell proliferation evaluated by the PCNA method. Male Wistar rats received either a standard diet or a high fat diet (HFD), supplemented or not with Orlistat (200mg/kg chow) and two doses of the carcinogen dimethyl-hydrazine (25mg/Kg). After 30 days, Orlistat was associated to a significant increase in the number of colonic ACFs and cell proliferation in DMH-treated animals, independently of the HFD.Entities:
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Year: 2005 PMID： 16377080 DOI： 10.1016/j.canlet.2005.09.011
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679