BACKGROUND: In food-restricted rats, leptin suppresses semistarvation-induced hyperactivity (SIH) and decreases exploratory behavior. Leptin ameliorates anxiety-related movement in ob/ob mice. In this study, we assessed the relationship between leptin and qualities of physical activity and restlessness in acute anorexia nervosa (AN). METHODS: Serum leptin, body mass index (BMI), % body fat, and self- and expert-ratings of qualities of physical activity and restlessness were assessed in 26 inpatients with acute AN. Accelerometry was also performed. Regression analyses were used to predict activity and restlessness using BMI, % body fat, and leptin levels as predictor variables. RESULTS: Leptin levels significantly contributed to the prediction of all measures of activity and restlessness. CONCLUSIONS: This is the first study linking hypoleptinemia in AN patients to subjective and objective measures of higher physical activity and motor and inner restlessness. Leptin may directly or indirectly (or both) influence behaviors and cognitions contributing to hyperactivity and motor restlessness.
BACKGROUND: In food-restricted rats, leptin suppresses semistarvation-induced hyperactivity (SIH) and decreases exploratory behavior. Leptin ameliorates anxiety-related movement in ob/ob mice. In this study, we assessed the relationship between leptin and qualities of physical activity and restlessness in acute anorexia nervosa (AN). METHODS: Serum leptin, body mass index (BMI), % body fat, and self- and expert-ratings of qualities of physical activity and restlessness were assessed in 26 inpatients with acute AN. Accelerometry was also performed. Regression analyses were used to predict activity and restlessness using BMI, % body fat, and leptin levels as predictor variables. RESULTS:Leptin levels significantly contributed to the prediction of all measures of activity and restlessness. CONCLUSIONS: This is the first study linking hypoleptinemia in AN patients to subjective and objective measures of higher physical activity and motor and inner restlessness. Leptin may directly or indirectly (or both) influence behaviors and cognitions contributing to hyperactivity and motor restlessness.
Authors: A Torsello; F Brambilla; L Tamiazzo; I Bulgarelli; D Rapetti; E Bresciani; V Locatelli Journal: J Endocrinol Invest Date: 2007-12 Impact factor: 4.256
Authors: Nancy Zucker; Ashley Moskovich; Cynthia M Bulik; Rhonda Merwin; Katherine Gaddis; Molly Losh; Joseph Piven; Henry R Wagner; Kevin S LaBar Journal: Int J Eat Disord Date: 2012-10-26 Impact factor: 4.861
Authors: Katherine Schaumberg; Elisabeth Welch; Lauren Breithaupt; Christopher Hübel; Jessica H Baker; Melissa A Munn-Chernoff; Zeynep Yilmaz; Stefan Ehrlich; Linda Mustelin; Ata Ghaderi; Andrew J Hardaway; Emily C Bulik-Sullivan; Anna M Hedman; Andreas Jangmo; Ida A K Nilsson; Camilla Wiklund; Shuyang Yao; Maria Seidel; Cynthia M Bulik Journal: Eur Eat Disord Rev Date: 2017-10-02
Authors: A A van Elburg; M J H Kas; J J G Hillebrand; R J C Eijkemans; H van Engeland Journal: J Neural Transm (Vienna) Date: 2007-05-26 Impact factor: 3.575