| Literature DB >> 16376311 |
M Ouardouz1, J-Y Xu, B R Sastry.
Abstract
gamma-Aminobutyric acid (GABA) is inhibitory in adult, but excitatory in neonatal, neurons. The switch from excitatory to inhibitory action is due to a negative shift in the equilibrium potential for the GABA(A) receptor-mediated postsynaptic current (E(GABA-PSC)). Here, we report that, in neonatal rat hippocampal CA1 neurons, presynaptic theta-burst activation induces not only a shift in E(GABA-PSC) towards that in adult neurons, but also a recruitment of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-receptor-mediated postsynaptic currents.Entities:
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Year: 2005 PMID： 16376311 DOI： 10.1016/j.brainres.2005.10.089
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252