Literature DB >> 16376078

New benzimidazoles as thrombopoietin receptor agonists.

Igor G Safonov1, Dirk A Heerding, Richard M Keenan, Alan T Price, Connie L Erickson-Miller, Christopher B Hopson, Jenna L Levin, Kenneth A Lord, Peter M Tapley.   

Abstract

A novel benzimidazole series of small-molecule thrombopoietin receptor agonists has been discovered. Herein, we discuss the preliminary exploration of structure-activity relationships within this chemotype.

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Year:  2006        PMID： 16376078     DOI： 10.1016/j.bmcl.2005.11.096

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Revealing eltrombopag's promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation.

Authors:  Christian A Di Buduo; Manuela Currao; Alessandro Pecci; David L Kaplan; Carlo L Balduini; Alessandra Balduini
Journal:  Haematologica       Date:  2016-08-11       Impact factor: 9.941

2.  Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation.

Authors:  Erin E Matthews; Damien Thévenin; Julia M Rogers; Lisa Gotow; Paul D Lira; Lawrence A Reiter; William H Brissette; Donald M Engelman
Journal:  FASEB J       Date:  2011-03-14       Impact factor: 5.191

3.  New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Authors:  Solene Guiheneuf; Ludovic Paquin; François Carreaux; Emilie Durieu; Thierry Roisnel; Laurent Meijer; Jean-Pierre Bazureau
Journal:  Mol Divers       Date:  2014-03-02       Impact factor: 2.943

Review 4.  New thrombopoietic growth factors.

Authors:  David J Kuter
Journal:  Blood       Date:  2007-02-08       Impact factor: 22.113

5.  The Eltrombopag antitumor effect on hepatocellular carcinoma.

Authors:  Tomohiro Kurokawa; Soichiro Murata; Yun-Wen Zheng; Kenichi Iwasaki; Keisuke Kohno; Kiyoshi Fukunaga; Nobuhiro Ohkohchi
Journal:  Int J Oncol       Date:  2015-09-23       Impact factor: 5.650

6.  Ultrasound-assisted synthesis of 2,4-thiazolidinedione and rhodanine derivatives catalyzed by task-specific ionic liquid: [TMG][Lac].

Authors:  Jagir Singh Sandhu
Journal:  Org Med Chem Lett       Date:  2013-03-03
  6 in total

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