Literature DB >> 16375675

Fungal sphingolipids as targets for the development of selective antifungal therapeutics.

K Thevissen1, I E J A Francois, A M Aerts, B P A Cammue.   

Abstract

Sphingolipids are essential membrane components, present in all eukaryotic cells, but structurally distinct in mammalian and fungal cells. Therefore, they represent an attractive new target for the development of novel antimycotics. This review will briefly highlight sphingolipid biosynthesis and functions in the yeast Saccharomyces cerevisiae. In addition, naturally occurring antifungal compounds that interact with fungal-specific sphingolipids, resulting in fungal growth arrest, will be discussed regarding their mode of action, and therapeutic value. These compounds include plant and insect defensins, syringomycin E and antifungal antibodies to sphingolipids.

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Year:  2005        PMID： 16375675     DOI： 10.2174/138945005774912771

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN： 1389-4501            Impact factor:   3.465


  13 in total

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Authors:  Kazi T Islam; Dilip M Shah; Kaoutar El-Mounadi
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Review 4.  Bioactive natural products from Lysobacter.

Authors:  Yunxuan Xie; Stephen Wright; Yuemao Shen; Liangcheng Du
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5.  Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation.

Authors:  Ali Abdul Lattif; Pranab K Mukherjee; Jyotsna Chandra; Mary R Roth; Ruth Welti; Mahmoud Rouabhia; Mahmoud A Ghannoum
Journal:  Microbiology (Reading)       Date:  2011-09-08       Impact factor: 2.777

6.  Structure-activity determinants in antifungal plant defensins MsDef1 and MtDef4 with different modes of action against Fusarium graminearum.

Authors:  Uma Shankar Sagaram; Raghoottama Pandurangi; Jagdeep Kaur; Thomas J Smith; Dilip M Shah
Journal:  PLoS One       Date:  2011-04-13       Impact factor: 3.240

Review 7.  1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma.

Authors:  Jingjing Duan; Alfred H Merrill
Journal:  J Biol Chem       Date:  2015-05-06       Impact factor: 5.157

8.  Identification of defensin-encoding genes of Picea glauca: characterization of PgD5, a conserved spruce defensin with strong antifungal activity.

Authors:  Pere Picart; Anna Maria Pirttilä; Dora Raventos; Hans-Henrik Kristensen; Hans-Georg Sahl
Journal:  BMC Plant Biol       Date:  2012-10-05       Impact factor: 4.215

Review 9.  Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols.

Authors:  Sarah T Pruett; Anatoliy Bushnev; Kerri Hagedorn; Madhura Adiga; Christopher A Haynes; M Cameron Sullards; Dennis C Liotta; Alfred H Merrill
Journal:  J Lipid Res       Date:  2008-05-21       Impact factor: 5.922

10.  Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: identification of an RGFRRR motif governing fungal cell entry.

Authors:  Uma Shankar Sagaram; Kaoutar El-Mounadi; Garry W Buchko; Howard R Berg; Jagdeep Kaur; Raghu S Pandurangi; Thomas J Smith; Dilip M Shah
Journal:  PLoS One       Date:  2013-12-04       Impact factor: 3.240
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