Literature DB >> 16372144

Midazolam inhibits neophobia-induced Fos expression in the rat hippocampus.

A Wisłowska-Stanek1, M Zienowicz, M Lehner, E Taracha, A Bidziński, P Maciejak, A Skórzewska, J Szyndler, A Płaźnik.   

Abstract

The effect of midazolam on expression of c-Fos protein was examined in the rat hippocampus, following the open field test of neophobia. It was found that pretreatment of rats with midazolam, at the dose of 0.5 mg/kg, enhanced rat exploratory behavior, and inhibited neophobia related stimulation of c-Fos in the CA-1 and CA-3 areas of the hippocampus. The presented results provide new immunocytochemical data on the involvement of hippocampus in emotional processes related to neophobia, and indicate a possible site of action of benzodiazepines.

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Year:  2006        PMID： 16372144     DOI： 10.1007/s00702-005-0398-x

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  19 in total

1.  The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon.

Authors:  W Wisden; D J Laurie; H Monyer; P H Seeburg
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2.  Single neurons in the dentate gyrus and CA1 of the hippocampus exhibit inverse patterns of encoding during trace fear conditioning.

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Review 3.  Which GABAA-receptor subtypes really occur in the brain?

Authors:  R M McKernan; P J Whiting
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4.  Limbic mechanisms of anxiolytics acting on 5-HT receptors.

Authors:  A Płaźnik; W Kostowski; R Stefański
Journal:  Pol J Pharmacol       Date:  1994 Sep-Oct

5.  The anxiolytic effects of intra-hippocampal midazolam are antagonized by intra-septal L-glutamate.

Authors:  J Menard; D Treit
Journal:  Brain Res       Date:  2001-01-05       Impact factor: 3.252

6.  Immunohistochemical studies on distribution of GABAA receptor complex in the rat brain using antibody against purified GABAA receptor complex.

Authors:  J Taguchi; T Kuriyama; Y Ohmori; K Kuriyama
Journal:  Brain Res       Date:  1989-04-03       Impact factor: 3.252

7.  The comparison of benzodiazepine derivatives and serotonergic agonists and antagonists in two animal models of anxiety.

Authors:  R Stefański; W Pałejko; W Kostowski; A Płaźnik
Journal:  Neuropharmacology       Date:  1992-12       Impact factor: 5.250

8.  Differential effects of midazolam on inhibitory postsynaptic currents in CA1 pyramidal cells and dentate gyrus granule cells of rat hippocampal slices.

Authors:  Suguru Kobayashi; Yutaka Fujito; Kiyoji Matsuyama; Mamoru Aoki
Journal:  Brain Res       Date:  2004-04-02       Impact factor: 3.252

9.  Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment.

Authors:  C H Beck; H C Fibiger
Journal:  J Neurosci       Date:  1995-01       Impact factor: 6.167

10.  Serotonergic innervation of the hippocampus and nucleus accumbens septi and the anxiolytic-like action of midazolam and 5-HT1A receptor agonists.

Authors:  R Stefański; W Pałejko; A Bidziński; W Kostowski; A Płaźnik
Journal:  Neuropharmacology       Date:  1993-10       Impact factor: 5.250
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