Literature DB >> 16372107

A novel heterocyclic atom exchange reaction with Lawesson's reagent: a one-pot synthesis of dithiomaltol.

Daniel Brayton1, Faith E Jacobsen, Seth M Cohen, Patrick J Farmer.   

Abstract

A one-pot reaction of maltol with Lawesson's reagent generates dithiomaltol, a thiopyran-4-thione, via an unusual heterocyclic atom exchange (HCAE) reaction; only pyrones with proton or aliphatic substituents undergo the HCAE substitution.

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Year:  2005        PMID： 16372107     DOI： 10.1039/b511966a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Synthesis of sulfur karrikin bioisosteres as potential neuroprotectives.

Authors:  Martin Pošta; Václav Zima; Lenka Poštová Slavětínská; Marika Matoušová; Petr Beier
Journal:  Beilstein J Org Chem       Date:  2022-05-16       Impact factor: 2.544

2.  Synthesis and structure-activity relationship of 3-hydroxypyridine-2-thione-based histone deacetylase inhibitors.

Authors:  Quaovi H Sodji; Vishal Patil; James R Kornacki; Milan Mrksich; Adegboyega K Oyelere
Journal:  J Med Chem       Date:  2013-12-12       Impact factor: 7.446

3.  The ionophore thiomaltol induces rapid lysosomal accumulation of copper and apoptosis in melanoma.

Authors:  Ottis Scrivner; Long Dao; M Karen Newell-Rogers; Babbak Shahandeh; Frank L Meyskens; Susan Kurumi Kozawa; Feng Liu-Smith; Germán Plascencia-Villa; Miguel José-Yacamán; Shang Jia; Christopher J Chang; Patrick J Farmer
Journal:  Metallomics       Date:  2022-01-17       Impact factor: 4.526

4.  Interaction of the O-Benzoyl-β-aminopropioamidoximes with Lawesson's Reagent and Spectral Characterization of the Products.

Authors:  Lyudmila Kayukova; Kaldubai Praliyev; Ulan Kemelbekov; Asel Abdildanova; Vanda Gutyar
Journal:  ISRN Org Chem       Date:  2012-03-22

5.  Exploring the influence of the protein environment on metal-binding pharmacophores.

Authors:  David P Martin; Patrick G Blachly; J Andrew McCammon; Seth M Cohen
Journal:  J Med Chem       Date:  2014-08-19       Impact factor: 7.446
  5 in total

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