Literature DB >> 16372096

Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum.

Arin Ghasparian1, Kerstin Moehle, Anthony Linden, John A Robinson.   

Abstract

A crystal structure is reported of the peptide Ac-Ala-Asn-Pro-Asn-Ala-NH2, representing the immunodominant region of the major surface protein on the malaria parasite; the NPNA motif adopts a type-I beta-turn, which is stabilized by hydrogen bonding between the CO of Asn2 and the NH of Ala5 as well as between the O(delta) of Asn2 and the NH of Asn4.

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Year:  2005        PMID： 16372096     DOI： 10.1039/b510812h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  26 in total

1.  Force Spectroscopy of the Plasmodium falciparum Vaccine Candidate Circumsporozoite Protein Suggests a Mechanically Pliable Repeat Region.

Authors:  Aditya Prasad Patra; Shobhona Sharma; Sri Rama Koti Ainavarapu
Journal:  J Biol Chem       Date:  2016-12-27       Impact factor: 5.157

2.  A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.

Authors:  Lawrence T Wang; Lais S Pereira; Yevel Flores-Garcia; James O'Connor; Barbara J Flynn; Arne Schön; Nicholas K Hurlburt; Marlon Dillon; Annie S P Yang; Amanda Fabra-García; Azza H Idris; Bryan T Mayer; Monica W Gerber; Raphael Gottardo; Rosemarie D Mason; Nicole Cavett; Reid B Ballard; Neville K Kisalu; Alvaro Molina-Cruz; Jorgen Nelson; Rachel Vistein; Carolina Barillas-Mury; Rogerio Amino; David Baker; Neil P King; Robert W Sauerwein; Marie Pancera; Ian A Cockburn; Fidel Zavala; Joseph R Francica; Robert A Seder
Journal:  Immunity       Date:  2020-09-17       Impact factor: 31.745

3.  The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria.

Authors:  Lawrence T Wang; Nicholas K Hurlburt; Arne Schön; Barbara J Flynn; Yevel Flores-Garcia; Lais S Pereira; Patience K Kiyuka; Marlon Dillon; Brian Bonilla; Fidel Zavala; Azza H Idris; Joseph R Francica; Marie Pancera; Robert A Seder
Journal:  Cell Rep       Date:  2022-02-15       Impact factor: 9.423

4.  Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate.

Authors:  Matthew L Plassmeyer; Karine Reiter; Richard L Shimp; Svetlana Kotova; Paul D Smith; Darrell E Hurt; Brent House; Xiaoyan Zou; Yanling Zhang; Merrit Hickman; Onyinyechukwu Uchime; Raul Herrera; Vu Nguyen; Jacqueline Glen; Jacob Lebowitz; Albert J Jin; Louis H Miller; Nicholas J MacDonald; Yimin Wu; David L Narum
Journal:  J Biol Chem       Date:  2009-07-24       Impact factor: 5.157

Review 5.  Repetitive sequences in malaria parasite proteins.

Authors:  Heledd M Davies; Stephanie D Nofal; Emilia J McLaughlin; Andrew R Osborne
Journal:  FEMS Microbiol Rev       Date:  2017-11-01       Impact factor: 16.408

6.  Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.

Authors:  Gianna Triller; Stephen W Scally; Giulia Costa; Maria Pissarev; Cornelia Kreschel; Alexandre Bosch; Eric Marois; Brandon K Sack; Rajagopal Murugan; Ahmed M Salman; Chris J Janse; Shahid M Khan; Stefan H I Kappe; Ayola A Adegnika; Benjamin Mordmüller; Elena A Levashina; Jean-Philippe Julien; Hedda Wardemann
Journal:  Immunity       Date:  2017-11-29       Impact factor: 31.745

7.  Structural insights into serine-rich fimbriae from Gram-positive bacteria.

Authors:  Stéphanie Ramboarina; James A Garnett; Meixian Zhou; Yuebin Li; Zhixiang Peng; Jonathan D Taylor; Wei-Chao Lee; Andrew Bodey; James W Murray; Yilmaz Alguel; Julien Bergeron; Benjamin Bardiaux; Elizabeth Sawyer; Rivka Isaacson; Camille Tagliaferri; Ernesto Cota; Michael Nilges; Peter Simpson; Teresa Ruiz; Hui Wu; Stephen Matthews
Journal:  J Biol Chem       Date:  2010-06-28       Impact factor: 5.157

8.  Virosome-formulated Plasmodium falciparum AMA-1 & CSP derived peptides as malaria vaccine: randomized phase 1b trial in semi-immune adults & children.

Authors:  Patrick Georges Cech; Thomas Aebi; Mwanajaa Shomari Abdallah; Maxmillian Mpina; Ester Barnabas Machunda; Nicole Westerfeld; Sabine Alexandra Stoffel; Rinaldo Zurbriggen; Gerd Pluschke; Marcel Tanner; Claudia Daubenberger; Blaise Genton; Salim Abdulla
Journal:  PLoS One       Date:  2011-07-22       Impact factor: 3.240

9.  T1BT* structural study of an anti-plasmodial peptide through NMR and molecular dynamics.

Authors:  Elena Topchiy; Geoffrey S Armstrong; Katherine I Boswell; Ginka S Buchner; Jan Kubelka; Teresa E Lehmann
Journal:  Malar J       Date:  2013-03-18       Impact factor: 2.979

10.  A randomized placebo-controlled phase Ia malaria vaccine trial of two virosome-formulated synthetic peptides in healthy adult volunteers.

Authors:  Blaise Genton; Gerd Pluschke; Lukas Degen; Andreas R Kammer; Nicole Westerfeld; Shinji L Okitsu; Sandro Schroller; Penelope Vounatsou; Markus M Mueller; Marcel Tanner; Rinaldo Zurbriggen
Journal:  PLoS One       Date:  2007-10-10       Impact factor: 3.240
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