Literature DB >> 16369176

Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers: impact of endoscopic technique (rigid vs. flexible laryngoscope).

Claudio F Milstein1, Samer Charbel, Douglas M Hicks, Tom I Abelson, Joel E Richter, Michael F Vaezi.   

Abstract

OBJECTIVES: The objectives of this study were to 1) determine the prevalence of ENT findings in the normal asymptomatic population and 2) to compare findings between flexible and rigid laryngoscopes in an attempt to increase specificity of diagnosis of reflux in endoscopic laryngeal examinations. STUDY
DESIGN: Prospective study.
METHODS: Fifty-two nonsmoker volunteers (24 male, 28 female), mean age of 42.7 years, with no history of ENT abnormalities or gastroesophageal reflux disease, underwent both rigid and flexible videolaryngologic examinations with a digital endoscopic unit. A group of three expert judges reviewed the oral and transnasal examinations blindly and independently for physical signs of irritation/inflammation commonly associated with reflux.
RESULTS: Atleast one sign of tissue irritation was detected in 93% and 83% of the population when using a flexible and a rigid laryngoscope, respectively. Results showed a high incidence of posterior commissure bar (53.2% and 51.9%), arytenoid complex edema/erythema (76.3% and 53.2%), and pseudosulcus (37.2% and 7.7%). Most signs were more frequently detected on flexible transasal examinations than with rigid transoral examinations: posterior pharyngeal wall (<0.01), interarytenoid irritation (<0.01), arytenoids complex irritation (<0.01), ventricular obliteration (<0.01), and pseudosulcus (<0.01).
CONCLUSIONS: Several signs of posterior laryngeal irritation (e.g., interarytenoid bar, erythema of the medial wall of the arytenoids), which are generally considered to be signs of laryngopharyngeal reflux, are present in a high percentage of nonsymptomatic individuals, raising question about their diagnostic specificity. In addition, these signs were more often detected with flexible than with rigid laryngoscopes, suggesting that flexible laryngoscopy is more sensitive but less specific in identifying laryngeal tissue irritation.

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Mesh:

Year:  2005        PMID: 16369176     DOI: 10.1097/01.mlg.0000184325.44968.b1

Source DB:  PubMed          Journal:  Laryngoscope        ISSN: 0023-852X            Impact factor:   3.325


  34 in total

1.  Hypopharyngeal pepsin and Sep70 as diagnostic markers of laryngopharyngeal reflux: preliminary study.

Authors:  Yoshihiro Komatsu; Lori A Kelly; Ali H Zaidi; Christina L Rotoloni; Juliann E Kosovec; Emily J Lloyd; Amina Waheed; Toshitaka Hoppo; Blair A Jobe
Journal:  Surg Endosc       Date:  2014-08-27       Impact factor: 4.584

2.  Laryngopharyngeal reflux in patients with reflux esophagitis.

Authors:  Yung-Chih Lai; Pa-Chun Wang; Jun-Chen Lin
Journal:  World J Gastroenterol       Date:  2008-07-28       Impact factor: 5.742

Review 3.  The posterior glottis: structural and clinical considerations.

Authors:  M N Kotby; E Kamal; A El-Makhzangy; A Nabil Khattab; P Milad
Journal:  Eur Arch Otorhinolaryngol       Date:  2012-05-22       Impact factor: 2.503

4.  Optimal treatment of laryngopharyngeal reflux disease.

Authors:  Irene Martinucci; Nicola de Bortoli; Edoardo Savarino; Andrea Nacci; Salvatore Osvaldo Romeo; Massimo Bellini; Vincenzo Savarino; Bruno Fattori; Santino Marchi
Journal:  Ther Adv Chronic Dis       Date:  2013-11       Impact factor: 5.091

Review 5.  Gastroesophageal reflux/laryngopharyngeal reflux disease: a critical analysis of the literature.

Authors:  M N Kotby; O Hassan; Aly M N El-Makhzangy; M Farahat; P Milad
Journal:  Eur Arch Otorhinolaryngol       Date:  2010-02       Impact factor: 2.503

Review 6.  Oropharyngeal Reflux Monitoring and Atypical Gastroesophageal Reflux Disease.

Authors:  Dhyanesh A Patel; Ali H Harb; Michael F Vaezi
Journal:  Curr Gastroenterol Rep       Date:  2016-03

Review 7.  Evaluation of patients with suspected laryngopharyngeal reflux: a practical approach.

Authors:  Anas Abou-Ismail; Michael F Vaezi
Journal:  Curr Gastroenterol Rep       Date:  2011-06

Review 8.  Upper aerodigestive tract disorders and gastro-oesophageal reflux disease.

Authors:  Andrea Ciorba; Chiara Bianchini; Michele Zuolo; Carlo Vittorio Feo
Journal:  World J Clin Cases       Date:  2015-02-16       Impact factor: 1.337

9.  Laryngopharyngeal Reflux and Functional Laryngeal Disorder: Perspective and Common Practice of the General Gastroenterologist.

Authors:  Dhyanesh A Patel; Michael Blanco; Michael F Vaezi
Journal:  Gastroenterol Hepatol (N Y)       Date:  2018-09

10.  New developments in extraesophageal reflux disease.

Authors:  Elif Saritas Yuksel; Michael F Vaezi
Journal:  Gastroenterol Hepatol (N Y)       Date:  2012-09
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