| Literature DB >> 16369038 |
Rosalind Polley1, Simona Stager, Sara Prickett, Asher Maroof, Soombul Zubairi, Deborah F Smith, Paul M Kaye.
Abstract
CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.Entities:
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Year: 2006 PMID: 16369038 PMCID: PMC1346645 DOI: 10.1128/IAI.74.1.773-776.2006
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441