BACKGROUND: In patients, after repair of aortic coarctation, abnormal function of the proximal precoarctation arterial conduits has been demonstrated, but data on arterial wall structure of proximal and distal arteries in patients are scarce. The aim of our study is to compare intima-media thickness (IMT) of the carotid and femoral arteries in controls and patients after coarctation repair and to identify independent predictors of carotid and femoral IMT. METHODS: A total of 137 patients after repair of aortic coarctation (89 male, median age 29.7 years, range 17-74 years, and median age at repair 6.3 years, range 0.01-46 years) and 46 age-matched controls underwent ambulatory blood pressure monitoring and B-mode ultrasound of the carotid and femoral arteries. RESULTS: Twenty (15%) of the 137 patients were operated on before the age of 1 year ("early repair"). The patients with an early repair were younger compared to the controls and compared with the patients with a late repair (24.5 [10.5] vs 31.6 [8.4] years, P = .005, and vs 32.1 [10.5] years, P < .001, respectively). Eighty patients (59%) had hypertension on the basis of the results of the ambulatory blood pressure monitoring (mean daytime blood pressure > or = 135/85 mm Hg). The prevalence of hypertension was not significantly different between patients with an early or late repair. Although patients with an early repair were younger, both carotid and femoral IMT were increased in these patients compared to controls (common carotid artery 0.57 [0.11] vs 0.49 [0.07] mm, P < .001; common femoral artery 0.48 [0.10] vs 0.44 [0.05] mm, P = .033). In multivariable regression analyses, age at repair was only an independent predictor of femoral and not of carotid IMT. CONCLUSIONS: Patients, after repair of aortic coarctation, have increased carotid and femoral IMT despite normal ambulatory blood pressures and successful previous repair. Early repair seems to preserve postcoarctation arterial wall structure, but seems to have only limited effect on precoarctation vessel walls, which supports the theory of a developmental defect of the proximal aorta and its branches.
BACKGROUND: In patients, after repair of aortic coarctation, abnormal function of the proximal precoarctation arterial conduits has been demonstrated, but data on arterial wall structure of proximal and distal arteries in patients are scarce. The aim of our study is to compare intima-media thickness (IMT) of the carotid and femoral arteries in controls and patients after coarctation repair and to identify independent predictors of carotid and femoral IMT. METHODS: A total of 137 patients after repair of aortic coarctation (89 male, median age 29.7 years, range 17-74 years, and median age at repair 6.3 years, range 0.01-46 years) and 46 age-matched controls underwent ambulatory blood pressure monitoring and B-mode ultrasound of the carotid and femoral arteries. RESULTS: Twenty (15%) of the 137 patients were operated on before the age of 1 year ("early repair"). The patients with an early repair were younger compared to the controls and compared with the patients with a late repair (24.5 [10.5] vs 31.6 [8.4] years, P = .005, and vs 32.1 [10.5] years, P < .001, respectively). Eighty patients (59%) had hypertension on the basis of the results of the ambulatory blood pressure monitoring (mean daytime blood pressure > or = 135/85 mm Hg). The prevalence of hypertension was not significantly different between patients with an early or late repair. Although patients with an early repair were younger, both carotid and femoral IMT were increased in these patients compared to controls (common carotid artery 0.57 [0.11] vs 0.49 [0.07] mm, P < .001; common femoral artery 0.48 [0.10] vs 0.44 [0.05] mm, P = .033). In multivariable regression analyses, age at repair was only an independent predictor of femoral and not of carotid IMT. CONCLUSIONS:Patients, after repair of aortic coarctation, have increased carotid and femoral IMT despite normal ambulatory blood pressures and successful previous repair. Early repair seems to preserve postcoarctation arterial wall structure, but seems to have only limited effect on precoarctation vessel walls, which supports the theory of a developmental defect of the proximal aorta and its branches.
Authors: Arjun Menon; David C Wendell; Hongfeng Wang; Thomas J Eddinger; Jeffrey M Toth; Ronak J Dholakia; Paul M Larsen; Eric S Jensen; John F Ladisa Journal: J Pharmacol Toxicol Methods Date: 2011-11-04 Impact factor: 1.950
Authors: Arjun Menon; Thomas J Eddinger; Hongfeng Wang; David C Wendell; Jeffrey M Toth; John F LaDisa Journal: Am J Physiol Heart Circ Physiol Date: 2012-09-28 Impact factor: 4.733
Authors: Carlos A Jesus; Jorge E Assef; Simone R F F Pedra; Waldinai P Ferreira; Tathiane A Davoglio; Ana Cláudia G P Petisco; Mohamed H Saleh; David C S Le Bihan; Rodrigo B M Barretto; Carlos A C Pedra Journal: Int J Cardiovasc Imaging Date: 2016-01-02 Impact factor: 2.357
Authors: Trisha V Vigneswaran; Manish D Sinha; Israel Valverde; John M Simpson; Marietta Charakida Journal: Pediatr Cardiol Date: 2017-10-17 Impact factor: 1.655
Authors: P Luijendijk; S M Boekholdt; N A Blom; M Groenink; A P Backx; B J Bouma; B J M Mulder; R J De Winter Journal: Neth Heart J Date: 2011-10 Impact factor: 2.380
Authors: Inga Voges; Julian Kees; Michael Jerosch-Herold; Hannes Gottschalk; Jens Trentmann; Christopher Hart; Dominik D Gabbert; Eileen Pardun; Minh Pham; Ana C Andrade; Philip Wegner; Ines Kristo; Olav Jansen; Hans-Heiner Kramer; Carsten Rickers Journal: J Cardiovasc Magn Reson Date: 2016-09-12 Impact factor: 5.364