| Literature DB >> 16368164 |
Francesca Cateni1, Jelena Zilic, Marina Zacchigna, Paolo Bonivento, Fabiana Frausin, Vito Scarcia.
Abstract
The synthesis of a series of alpha-methylene-gamma-butyrolactones (compounds 4a, 4b, 6-12, 16, 17) and alpha,beta-unsaturated-delta-lactones (compounds 19-23, 25, 26) starting from 4,4-dimethyldihydrofuran-2,3-dione (1) has been described. Their chemical structures were assigned by spectroscopic evidence. These new compounds exhibited significantly different antiproliferative properties against cultured human tumor cell lines with their IC(50) values ranging from 0.88 to>20.00 microM.Entities:
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Year: 2005 PMID： 16368164 DOI： 10.1016/j.ejmech.2005.10.009
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514