| Literature DB >> 16368124 |
Elisabetta Caselli1, Arianna Bracci, Monica Galvan, Michela Boni, Antonella Rotola, Carlo Bergamini, Claudio Cermelli, Paola Dal Monte, Ursula A Gompels, Enzo Cassai, Dario Di Luca.
Abstract
Human herpesvirus 6 (HHV-6) is the only human herpesvirus encoding U94/rep, homologue to the parvovirus non-structural gene rep68/78. Results to date suggest that HHV-6 U94/rep might regulate viral gene expression and have a role in viral latency. To determine the effect of U94/REP upon viral replication, the protein was produced. The purified U94/REP retained the characteristic immunological features. It was internalized and localized in the nucleus of human cells, showing marked inhibitory activity on the replication of HHV-6 (both variants A and B). The effect of U94/REP was dose-dependent and sensitive to treatment with single-stranded but not double-stranded DNA. U94/REP inhibited the replication of other betaherpesviruses, HHV-7 and human cytomegalovirus, but had no effect on herpes simplex virus. These results confirm the action of U94/rep latency gene in the regulation of HHV-6 replication with implications for co-reactivations and latency of human betaherpesviruses.Entities:
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Year: 2005 PMID： 16368124 DOI： 10.1016/j.virol.2005.11.018
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616