Literature DB >> 16364639

Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands.

Raman K Bakshi1, Qingmei Hong, Rui Tang, Rubana N Kalyani, Tanya Macneil, David H Weinberg, Lex H T Van der Ploeg, Arthur A Patchett, Ravi P Nargund.   

Abstract

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.

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Year:  2005        PMID: 16364639     DOI: 10.1016/j.bmcl.2005.11.095

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  The MC4 receptor and control of appetite.

Authors:  R A H Adan; B Tiesjema; J J G Hillebrand; S E la Fleur; M J H Kas; M de Krom
Journal:  Br J Pharmacol       Date:  2006-10-16       Impact factor: 8.739

Review 2.  Alpha-melanocyte stimulating hormone: production and degradation.

Authors:  Giuseppe D'Agostino; Sabrina Diano
Journal:  J Mol Med (Berl)       Date:  2010-07-10       Impact factor: 4.599

3.  Regioselective One-Pot Synthesis, Biological Activity and Molecular Docking Studies of Novel Conjugates N-(p-Aryltriazolyl)-1,5-benzodiazepin-2-ones as Potent Antibacterial and Antifungal Agents.

Authors:  Asma Nsira; Hasan Mtiraoui; Sami Chniti; Hanan Al-Ghulikah; Rafik Gharbi; Moncef Msaddek
Journal:  Molecules       Date:  2022-06-22       Impact factor: 4.927

  3 in total

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