| Literature DB >> 16364611 |
Christopher J Endres1, Peng Hsiao, Francisco S Chung, Jashvant D Unadkat.
Abstract
Transport proteins play an important role in the adsorption, distribution and elimination of a wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions can occur in the clinic. These interactions can lead to changes in toxicity and/or efficacy of the affected drug. Here, we review such interactions and ask if these interactions could have been predicted from in vitro data. Conducting such in vitro-in vivo correlation is important for predicting future transporter-based drug interactions.Entities:
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Year: 2005 PMID： 16364611 DOI： 10.1016/j.ejps.2005.11.002
Source DB: PubMed Journal: Eur J Pharm Sci ISSN： 0928-0987 Impact factor: 4.384