Literature DB >> 16364585

Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery.

Shobha N Bhattachar1, James A Wesley, Christopher Seadeek.   

Abstract

Solubility measurements using chemiluminescent nitrogen detection (CLND) has advantages of reduced compound requirement and increased throughput compared to UV-spectrophotometric and HPLC-based measurements. CLND with direct flow injection was evaluated for the measurement of thermodynamic solubility to support drug discovery. The limit of quantitation (LOQ), accuracy, and day-to-day reproducibility of the detector were measured. Measurements made on CLND were compared to those obtained from UV spectrophotometry and HPLC. Based on the results obtained, it was concluded that the CLND performs satisfactorily for discovery stage thermodynamic solubility measurements.

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Year:  2005        PMID： 16364585     DOI： 10.1016/j.jpba.2005.11.009

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  7 in total

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2.  Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.

Authors:  Hongmao Sun; Pranav Shah; Kimloan Nguyen; Kyeong Ri Yu; Ed Kerns; Md Kabir; Yuhong Wang; Xin Xu
Journal:  Bioorg Med Chem       Date:  2019-05-27       Impact factor: 3.641

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Authors:  Rajarshi Guha; Thomas S Dexheimer; Aimee N Kestranek; Ajit Jadhav; Andrew M Chervenak; Michael G Ford; Anton Simeonov; Gregory P Roth; Craig J Thomas
Journal:  Bioorg Med Chem       Date:  2011-05-13       Impact factor: 3.641

4.  Binary classification of aqueous solubility using support vector machines with reduction and recombination feature selection.

Authors:  Tiejun Cheng; Qingliang Li; Yanli Wang; Stephen H Bryant
Journal:  J Chem Inf Model       Date:  2011-01-07       Impact factor: 4.956

5.  Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.

Authors:  Rosario Diaz; Sandra A Luengo-Arratta; João D Seixas; Emanuele Amata; William Devine; Carlos Cordon-Obras; Domingo I Rojas-Barros; Elena Jimenez; Fatima Ortega; Sabrinia Crouch; Gonzalo Colmenarejo; Jose Maria Fiandor; Jose Julio Martin; Manuela Berlanga; Silvia Gonzalez; Pilar Manzano; Miguel Navarro; Michael P Pollastri
Journal:  PLoS Negl Trop Dis       Date:  2014-10-23

6.  Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.

Authors:  Adrian Richter; Ines Rudolph; Ute Möllmann; Kerstin Voigt; Chun-Wa Chung; Onkar M P Singh; Michael Rees; Alfonso Mendoza-Losana; Robert Bates; Lluís Ballell; Sarah Batt; Natacha Veerapen; Klaus Fütterer; Gurdyal Besra; Peter Imming; Argyrides Argyrou
Journal:  Sci Rep       Date:  2018-09-07       Impact factor: 4.379

7.  Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness.

Authors:  João D Seixas; Sandra A Luengo-Arratta; Rosario Diaz; Manuel Saldivia; Domingo I Rojas-Barros; Pilar Manzano; Silvia Gonzalez; Manuela Berlanga; Terry K Smith; Miguel Navarro; Michael P Pollastri
Journal:  J Med Chem       Date:  2014-05-21       Impact factor: 7.446
  7 in total

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