Literature DB >> 16362659

Association between migraine and HLA-DRB1 gene polymorphisms.

Innocenzo Rainero1, Edvige Fasano, Elisa Rubino, Chiara Rivoiro, Walter Valfrè, Salvatore Gallone, Lidia Savi, Salvatore Gentile, Rossana Lo Giudice, Paola De Martino, Anna Maria Dall'Omo, Lorenzo Pinessi.   

Abstract

We examined the distribution of HLA-DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA-DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients. We conclude that, in Italian patients, migraine is associated with different alleles of the HLA-DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region.

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Year:  2005        PMID： 16362659      PMCID： PMC3452004          DOI： 10.1007/s10194-005-0180-3

Source DB:  PubMed          Journal:  J Headache Pain        ISSN： 1129-2369            Impact factor:   7.277


  6 in total

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Review 2.  A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine.

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5.  The Potential Role of Preoperative Pain, Catastrophizing, and Differential Gene Expression on Pain Outcomes after Pediatric Spinal Fusion.

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Review 6.  Genetics of migraine and pharmacogenomics: some considerations.

Authors:  Maria Piane; Patrizia Lulli; Ivano Farinelli; Simona Simeoni; Sergio De Filippis; Francesca Romana Patacchioli; Paolo Martelletti
Journal:  J Headache Pain       Date:  2007-12-05       Impact factor: 7.277
  6 in total

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