BACKGROUND: Multiple sclerosis (MS) has been reported to be associated with extensive autonomic dysfunction as well as to involve the cardiovascular system. In this study we compared P wave duration and dispersion (PWD) of MS patients to healthy control subjects. METHOD: Thirty-one MS patients (mean age 35 +/- 9 years) and 33 healthy control subjects (mean age 34+/-7 years) were included in the study. Twelve-lead surface ECG recording (paper speed of 50 mm/s) was obtained from all participants. The change in maximum and minimum P wave duration was measured manually and the difference between the two values was defined as PWD. RESULTS: There was no difference between the two groups in terms of baseline demographic characteristics. Maximum P wave duration was higher in MS patients than controls (126 +/- 6 vs. 122 +/- 5 ms, p = 0.004). Minimum P wave duration was found to be similar in MS patients and healthy controls (72 +/- 8 vs. 75 +/- 8 ms, p = 0.2). Mean PWD value of MS patients was also found to be higher than those of controls (53 +/- 10 vs. 47 +/- 10 ms, p = 0.01). CONCLUSION: P wave duration and PWD was found to be statistically different in patients with MS and control subjects.
BACKGROUND:Multiple sclerosis (MS) has been reported to be associated with extensive autonomic dysfunction as well as to involve the cardiovascular system. In this study we compared P wave duration and dispersion (PWD) of MSpatients to healthy control subjects. METHOD: Thirty-one MSpatients (mean age 35 +/- 9 years) and 33 healthy control subjects (mean age 34+/-7 years) were included in the study. Twelve-lead surface ECG recording (paper speed of 50 mm/s) was obtained from all participants. The change in maximum and minimum P wave duration was measured manually and the difference between the two values was defined as PWD. RESULTS: There was no difference between the two groups in terms of baseline demographic characteristics. Maximum P wave duration was higher in MSpatients than controls (126 +/- 6 vs. 122 +/- 5 ms, p = 0.004). Minimum P wave duration was found to be similar in MSpatients and healthy controls (72 +/- 8 vs. 75 +/- 8 ms, p = 0.2). Mean PWD value of MSpatients was also found to be higher than those of controls (53 +/- 10 vs. 47 +/- 10 ms, p = 0.01). CONCLUSION: P wave duration and PWD was found to be statistically different in patients with MS and control subjects.
Authors: K Aytemir; N Ozer; E Atalar; E Sade; S Aksöyek; K Ovünç; A Oto; F Ozmen; S Kes Journal: Pacing Clin Electrophysiol Date: 2000-07 Impact factor: 1.976
Authors: Oliver Findling; Larissa Hauer; Thomas Pezawas; Paulus S Rommer; Walter Struhal; Johann Sellner Journal: J Clin Med Date: 2020-01-24 Impact factor: 4.241