| Literature DB >> 1636163 |
M Nakamura1, H Konno, T Tanaka, Y Maruo, N Nishino, K Aoki, S Baba, S Sakaguchi, Y Takada, A Takada.
Abstract
The concentrations of urinary type plasminogen activator (u-PA), plasminogen activator inhibitor 1 (PAI-1), and PAI-2 were measured in gastric cancer tissues and adjacent healthy mucosal tissues. Levels of u-PA, PAI-1 and PAI-2 were higher in cancer than in control tissues. PAI-1 levels were higher together with the progression of cancer however there were no differences in u-PA or PAI-2 levels. Tumors with higher PAI-1 and lower PAI-2 levels tend to metastasize to remote lymph nodes. When the numbers of involved lymph nodes were analyzed, tumors with the large number of metastatic lymph nodes showed higher PAI-1 and lower PAI-2 level. No difference was shown in u-PA levels among these groups. These tendencies were more significant in patients with progressed gastric cancer. These results suggest that tumor with higher PAI-2 levels tend to localize or have less tendency to metastasize to lymph nodes. On the other hand PAI-1 was generally higher in tumor with invasion into nearby tissue or with nodal metastasis.Entities:
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Year: 1992 PMID： 1636163 DOI： 10.1016/0049-3848(92)90110-v
Source DB: PubMed Journal: Thromb Res ISSN： 0049-3848 Impact factor: 3.944