P Manganotti1, L G Bongiovanni, G Fuggetta, G Zanette, A Fiaschi. 1. Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Policlinico Borgo Roma, Via delle Menegone, 37134 Verona, Italy. paolo.manganotti@univr.it
Abstract
OBJECTIVE: To investigate the effect of sleep deprivation on corticospinal excitability in patients affected by juvenile myoclonic epilepsy (JME) using different transcranial magnetic stimulation (TMS) parameters. METHODS: Ten patients with JME and 10 normal subjects underwent partial sleep deprivation. Motor threshold (MT), motor evoked potential amplitude (MEP), and silent period (SP) were recorded from the thenar eminence (TE) muscles. Short latency intracortical inhibition (SICI) and short latency intracortical facilitation (SICF) were studied using paired magnetic stimulation. TMS was performed before and after sleep deprivation; EEG and TMS were performed simultaneously. RESULTS: In patients with JME, sleep deprivation induced a significant decrease in SICI and an increase in SICF, which was associated with increased paroxysmal activity. A significant decrease in the MT was observed. No significant changes in any TMS parameters were noted in normal subjects after sleep deprivation. The F wave was unchanged by sleep deprivation in both control subjects and in patients with JME. CONCLUSIONS: In patients with JME, sleep deprivation produces increases in corticospinal excitability in motor areas as measured by different TMS parameters.
OBJECTIVE: To investigate the effect of sleep deprivation on corticospinal excitability in patients affected by juvenile myoclonic epilepsy (JME) using different transcranial magnetic stimulation (TMS) parameters. METHODS: Ten patients with JME and 10 normal subjects underwent partial sleep deprivation. Motor threshold (MT), motor evoked potential amplitude (MEP), and silent period (SP) were recorded from the thenar eminence (TE) muscles. Short latency intracortical inhibition (SICI) and short latency intracortical facilitation (SICF) were studied using paired magnetic stimulation. TMS was performed before and after sleep deprivation; EEG and TMS were performed simultaneously. RESULTS: In patients with JME, sleep deprivation induced a significant decrease in SICI and an increase in SICF, which was associated with increased paroxysmal activity. A significant decrease in the MT was observed. No significant changes in any TMS parameters were noted in normal subjects after sleep deprivation. The F wave was unchanged by sleep deprivation in both control subjects and in patients with JME. CONCLUSIONS: In patients with JME, sleep deprivation produces increases in corticospinal excitability in motor areas as measured by different TMS parameters.
Authors: P M Rossini; A T Barker; A Berardelli; M D Caramia; G Caruso; R Q Cracco; M R Dimitrijević; M Hallett; Y Katayama; C H Lücking Journal: Electroencephalogr Clin Neurophysiol Date: 1994-08
Authors: Paolo Manganotti; Stefano Tamburin; Luigi Giuseppe Bongiovanni; Giampietro Zanette; Antonio Fiaschi Journal: Epilepsia Date: 2004-01 Impact factor: 5.864
Authors: Mirko Avesani; Emanuela Formaggio; Giorgio Fuggetta; Antonio Fiaschi; Paolo Manganotti Journal: Exp Brain Res Date: 2008-01-30 Impact factor: 1.972
Authors: Paolo Manganotti; Emanuela Formaggio; Alessandra Del Felice; Silvia F Storti; Alessandro Zamboni; Alessandra Bertoldo; Antonio Fiaschi; Gianna M Toffolo Journal: Front Hum Neurosci Date: 2013-11-18 Impact factor: 3.169