L Yang1, Z-G Zhou, H-Z Luo, B Zhou, Q-J Xia, C Tian. 1. Department of General Surgery and Division of Digestive Surgery and Organ-Microcirculation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Abstract
AIM: The purpose of this study is to clarify the expression change of PPARdelta gene in human colorectal cancer tissues. METHODS: Applying real-time RT-PCR, we quantified PPARdelta mRNA in a series of 86 tissues from excised primary rectal cancers. In each case, accompanying normal mucosa was collected for comparison. RESULTS: Among the 86 rectal cancer tissues, 48 cases showed PPARdelta overexpression: 39 tumours gave an expression level 1.5-5 times, five tumours 10-20 times, and four tumours more than 20 times relative to normal mucosa. However, the general level of PPARdelta mRNA in rectal cancer tissues is not statistically different from normal mucosa. CONCLUSIONS: The expression of PPARdelta gene in rectal cancers is not statistically different from normal mucosa.
AIM: The purpose of this study is to clarify the expression change of PPARdelta gene in humancolorectal cancer tissues. METHODS: Applying real-time RT-PCR, we quantified PPARdelta mRNA in a series of 86 tissues from excised primary rectal cancers. In each case, accompanying normal mucosa was collected for comparison. RESULTS: Among the 86 rectal cancer tissues, 48 cases showed PPARdelta overexpression: 39 tumours gave an expression level 1.5-5 times, five tumours 10-20 times, and four tumours more than 20 times relative to normal mucosa. However, the general level of PPARdelta mRNA in rectal cancer tissues is not statistically different from normal mucosa. CONCLUSIONS: The expression of PPARdelta gene in rectal cancers is not statistically different from normal mucosa.
Authors: O Takayama; H Yamamoto; B Damdinsuren; Y Sugita; C Y Ngan; X Xu; T Tsujino; I Takemasa; M Ikeda; M Sekimoto; N Matsuura; M Monden Journal: Br J Cancer Date: 2006-09-12 Impact factor: 7.640